ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
In vitro analog of operant conditioning in aplysia. I. Contingent reinforcement modifies the functional dynamics of an identified neuron.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
- Motor priming is associated with widespread recruitment into neural ensembles and more rapid ensemble transitions.iScience · 2026Article
- Low-dimensional signatures of neuronal activity associated with long-term operant conditioning in Aplysia.Communications biology · 2025Article
- Identified neurons B4/B5 function as sensory neurons, motor neurons, and interneurons inJournal of neurophysiology · 2025Article
- Voltage- and Calcium-Gated Membrane Currents Tune the Plateau Potential Properties of Multiple Neuron Types.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Specific Plasticity Loci and Their Synergism Mediate Operant Conditioning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Using an invertebrate model to investigate the mechanisms of short-term memory deficits induced by food deprivation.Behavioural brain research · 2022Article
- Neuronal population activity dynamics reveal a low-dimensional signature of operant learning in Aplysia.Communications biology · 2022Article
- Dopamine as a Multifunctional Neurotransmitter in Gastropod Molluscs: An Evolutionary Hypothesis.The Biological bulletin · 2020Review
- Computational model of the distributed representation of operant reward memory: combinatoric engagement of intrinsic and synaptic plasticity mechanisms.Learning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- Critical role of protein kinase G in the long-term balance between defensive and appetitive behaviors induced by aversive stimuli in Aplysia.Behavioural brain research · 2020Article
- Network Degeneracy and the Dynamics of Task Switching in the Feeding Circuit inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- The contributions and mechanisms of changes in excitability during simple forms of learning in Aplysia.Neurobiology of learning and memory · 2019Article
- Successful and unsuccessful attempts to swallow in a reducedLearning & memory (Cold Spring Harbor, N.Y.) · 2019Article
- Role of nitric oxide in the induction of the behavioral and cellular changes produced by a common aversive stimulus in Aplysia.Behavioural brain research · 2019Article
- cGMP mediates short- and long-term modulation of excitability in a decision-making neuron in Aplysia.Neuroscience letters · 2018Article
- NO is required for memory formation and expression of memory, and for minor behavioral changes during training with inedible food inLearning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- Inferring neuronal network functional connectivity with directed information.Journal of neurophysiology · 2017Article
- A novel in vitro analog expressing learning-induced cellular correlates in distinct neural circuits.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Long-term sensitization training inLearning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Repetition priming of motor activity mediated by a central pattern generator: the importance of extrinsic vs. intrinsic program initiators.Journal of neurophysiology · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Previously, an analog of operant conditioning in Aplysia was developed using the rhythmic motor activity in the isolated buccal ganglia. This analog expressed a key feature of operant conditioning, namely a selective enhancement in the occurrence of a designated motor pattern by contingent reinforcement. Different motor patterns generated by the buccal central pattern generator were induced by monotonic stimulation of a peripheral nerve (i.e., n.2,3). Phasic stimulation of the esophageal nerve (E n.) was used as an analog of reinforcement. The present study investigated the neuronal mechanisms associated with the genesis of different motor patterns and their modifications by contingent reinforcement. The genesis of different motor patterns was related to changes in the functional states of the pre-motor neuron B51. During rhythmic activity, B51 dynamically switched between inactive and active states. Bursting activity in B51 was associated with, and predicted, characteristic features of a specific motor pattern (i.e., pattern I). Contingent reinforcement of pattern I modified the dynamical properties of B51 by decreasing its resting conductance and threshold for eliciting plateau potentials and thus increased the occurrences of pattern I-related activity in B51. These modifications were not observed in preparations that received either noncontingent reinforcement (i.e., yoke control) or no reinforcement (i.e., control). These results suggest that a contingent reinforcement paradigm can regulate the dynamics of neuronal activity that is centrally programmed by the intrinsic cellular properties of neurons.
Indexed as
Identifiers
10066276PMC6782538What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.