ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Leukemia inhibitory factor and ciliary neurotrophic factor cause dendritic retraction in cultured rat sympathetic neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed, 60 citations in OpenAlex.
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- MicroRNAs are Necessary for BMP-7-induced Dendritic Growth in Cultured Rat Sympathetic Neurons.Cellular and molecular neurobiology · 2019Article
- An Antagonistic Axon-Dendrite Interplay Enables Efficient Neuronal Repair in the Adult Zebrafish Central Nervous System.Molecular neurobiology · 2019Article
- Mechanisms of organophosphorus pesticide toxicity in the context of airway hyperreactivity and asthma.American journal of physiology. Lung cellular and molecular physiology · 2018Review
- The neuroimmunology of degeneration and regeneration in the peripheral nervous system.Neuroscience · 2015Review
- Effects of kinesin-5 inhibition on dendritic architecture and microtubule organization.Molecular biology of the cell · 2015Article
- Dendrite complexity of sympathetic neurons is controlled during postnatal development by BMP signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Long-term gene therapy causes transgene-specific changes in the morphology of regenerating retinal ganglion cells.PloS one · 2012Article
- Rit signaling contributes to interferon-gamma-induced dendritic retraction via p38 mitogen-activated protein kinase activation.Journal of neurochemistry · 2008Article
- Structural plasticity of the adult brain: how animal models help us understand brain changes in depression and systemic disorders related to depression.Dialogues in clinical neuroscience · 2004Article
- Extracellular signal-regulated kinases regulate dendritic growth in rat sympathetic neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal peptide inhibit dendritic growth in cultured sympathetic neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Interferon gamma induces retrograde dendritic retraction and inhibits synapse formation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Leukemia inhibitory factor determines the growth status of injured adult sensory neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Small GTPases Rac and Rho in the maintenance of dendritic spines and branches in hippocampal pyramidal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Ciliary neurotrophic factor and stress stimuli activate the Jak-STAT pathway in retinal neurons and glia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Brain-derived neurotrophic factor differentially regulates retinal ganglion cell dendritic and axonal arborization in vivo.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dendritic retraction occurs in many regions of the developing brain and also after neural injury. However, the molecules that regulate this important regressive process remain largely unknown. Our data indicate that leukemia inhibitory factor (LIF) and ciliary neurotrophic factor (CNTF) cause sympathetic neurons to retract their dendrites in vitro, ultimately leading to an approximately 80% reduction in the size of the arbor. The dendritic retraction induced by LIF exhibited substantial specificity because it was not accompanied by changes in cell number, in the rate of axonal growth, or in the expression of axonal cytoskeletal elements. An antibody to gp130 blocked the effects of LIF and CNTF, and both cytokines induced phosphorylation and nuclear translocation of stat3. Moreover, addition of soluble interleukin-6 (IL-6) receptor to the medium endowed IL-6 with the ability to cause dendritic regression. These data indicate that ligands activating the gp130 pathway have the ability to profoundly alter neuronal cell shape and polarity by selectively causing the retraction of dendrites.
Indexed as
Identifiers
10066264PMC6782564W2159123872What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.