ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Myelin and collapsin-1 induce motor neuron growth cone collapse through different pathways: inhibition of collapse by opposing mutants of rac1.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
62 citing papers in PubMed, 185 citations in OpenAlex.
- Trio and CRMP2 regulate axon branching and Semaphorin3A signaling.Communications biology · 2025Article
- Article
- P-Rex1 Overexpression Results in Aberrant Neuronal Polarity and Psychosis-Related Behaviors.Neuroscience bulletin · 2019Article
- Rac GTPases: domain-specific functions in neuronal development.Neural regeneration research · 2019Article
- Regulators of Rho GTPases in the Nervous System: Molecular Implication in Axon Guidance and Neurological Disorders.International journal of molecular sciences · 2019Review
- Structural mechanisms of plexin signaling.Progress in biophysics and molecular biology · 2015Review
- Transmembrane proteoglycans syndecan-2, 4, receptor candidates for the impact of HGF and FGF2 on semaphorin 3A expression in early-differentiated myoblasts.Physiological reports · 2015Article
- Cdc42 and RhoA reveal different spatio-temporal dynamics upon local stimulation with Semaphorin-3A.Frontiers in cellular neuroscience · 2015Article
- The role of soluble adenylyl cyclase in neurite outgrowth.Biochimica et biophysica acta · 2014Review
- Inhibiting geranylgeranylation increases neurite branching and differentially activates cofilin in cell bodies and growth cones.Molecular neurobiology · 2014Article
- G-protein-coupled receptor cell signaling pathways mediating embryonic chick retinal growth cone collapse induced by lysophosphatidic acid and sphingosine-1-phosphate.Developmental neuroscience · 2014Article
- Oxygen radicals elicit paralysis and collapse of spinal cord neuron growth cones upon exposure to proinflammatory cytokines.BioMed research international · 2014Article
- Atypical protein kinase C and Par3 are required for proteoglycan-induced axon growth inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- LDL receptor-related protein-1 is a sialic-acid-independent receptor for myelin-associated glycoprotein that functions in neurite outgrowth inhibition by MAG and CNS myelin.Journal of cell science · 2013Article
- Axon guidance in the developing ocular motor system and Duane retraction syndrome depends on Semaphorin signaling via alpha2-chimaerin.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Merlin/NF2 regulates angiogenesis in schwannomas through a Rac1/semaphorin 3F-dependent mechanism.Neoplasia (New York, N.Y.) · 2012Article
- Extracellular inhibitors, repellents, and semaphorin/plexin/MICAL-mediated actin filament disassembly.Cytoskeleton (Hoboken, N.J.) · 2011Review
- Rho GTPases as regulators of morphological neuroplasticity.Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft · 2011Review
- Anti-ganglioside antibody-mediated activation of RhoA induces inhibition of neurite outgrowth.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- RHO GTPase signaling for axon extension: is prenylation important?Molecular neurobiology · 2010Review
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Precise growth cone guidance is the consequence of a continuous reorganization of actin filament structures within filopodia and lamellipodia in response to inhibitory and promoting cues. The small GTPases rac1, cdc42, and rhoA are critical for regulating distinct actin structures in non-neuronal cells and presumably in growth cones. Collapse, a retraction of filopodia and lamellipodia, is a typical growth cone behavior on contact with inhibitory cues and is associated with depolymerization and redistribution of actin filaments. We examined whether small GTPases mediate the inhibitory properties of CNS myelin or collapsin-1, a soluble semaphorin, in chick embryonic motor neuron cultures. As demonstrated for collapsin-1, CNS myelin-evoked growth cone collapse was accompanied by a reduction of rhodamine-phalloidin staining most prominent in the growth cone periphery, suggesting actin filament disassembly. Specific mutants of small GTPases were capable of desensitizing growth cones to CNS myelin or collapsin-1. Adenoviral-mediated expression of constitutively active rac1 or rhoA abolished CNS myelin-induced collapse and allowed remarkable neurite extension on a CNS myelin substrate. In contrast, expression of dominant negative rac1 or cdc42 negated collapsin-1-induced growth cone collapse and promoted neurite outgrowth on a collapsin-1 substrate. These findings suggest that small GTPases can modulate the signaling pathways of inhibitory stimuli and, consequently, allow the manipulation of growth cone behavior. However, the fact that opposite mutants of rac1 were effective against different inhibitory stimuli speaks against a universal signaling pathway underlying growth cone collapse.
Indexed as
Identifiers
10066250PMC6782563W1646460047What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.