ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Temperature-dependent modulation of excitatory transmission in hippocampal slices is mediated by extracellular adenosine.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 102 citations in OpenAlex.
- Local variation in brain temperature explains gender-specificity of working memory performance.Frontiers in human neuroscience · 2024Article
- Adenosine A1 Receptors Play an Important Protective Role Against Cognitive Impairment and Long-Term Potentiation Inhibition in a Pentylenetetrazol Mouse Model of Epilepsy.Molecular neurobiology · 2018Article
- Adenosine Differentially Modulates Synaptic Transmission of Excitatory and Inhibitory Microcircuits in Layer 4 of Rat Barrel Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Multiple pathways for elevating extracellular adenosine in the rat hippocampal CA1 region characterized by adenosine sensor cells.Journal of neurochemistry · 2017Article
- Metabolic Therapy for Temporal Lobe Epilepsy in a Dish: Investigating Mechanisms of Ketogenic Diet using Electrophysiological Recordings in Hippocampal Slices.Frontiers in molecular neuroscience · 2016Review
- Separate Ionotropic and Metabotropic Glutamate Receptor Functions in Depotentiation vs. LTP: A Distinct Role for Group1 mGluR Subtypes and NMDARs.Frontiers in cellular neuroscience · 2016Article
- Postsynaptic adenosine A2A receptors modulate intrinsic excitability of pyramidal cells in the rat basolateral amygdala.The international journal of neuropsychopharmacology · 2015Article
- Effects of dawn simulation on markers of sleep inertia and post-waking performance in humans.European journal of applied physiology · 2014Article
- Many parameter sets in a multicompartment model oscillator are robust to temperature perturbations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Presynaptic adenosine A₁ receptors modulate excitatory transmission in the rat basolateral amygdala.Neuropharmacology · 2014Article
- Article
- Purines and neuronal excitability: links to the ketogenic diet.Epilepsy research · 2012Review
- Differential contributions of adenosine to hypoxia-evoked depressions of three neuronal pathways in isolated spinal cord of neonatal rats.British journal of pharmacology · 2011Article
- The relationship between the neuromodulator adenosine and behavioral symptoms of autism.Neuroscience letters · 2011Article
- Cardioprotection by mild hypothermia during ischemia involves preservation of ERK activity.Basic research in cardiology · 2011Article
- Purinergic mechanisms in gliovascular coupling.Seminars in cell & developmental biology · 2011Review
- Calcium-independent inhibitory G-protein signaling induces persistent presynaptic muting of hippocampal synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Adenosine Release Evoked by Short Electrical Stimulations in Striatal Brain Slices is Primarily Activity Dependent.ACS chemical neuroscience · 2010Article
- Metabolic autocrine regulation of neurons involves cooperation among pannexin hemichannels, adenosine receptors, and KATP channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Control of cannabinoid CB1 receptor function on glutamate axon terminals by endogenous adenosine acting at A1 receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Although extracellular adenosine concentrations in brain are increased markedly by a variety of stimuli such as hypoxia and ischemia, it has been difficult to demonstrate large increases in adenosine with stimuli that do not result in pathological tissue damage. The present studies demonstrate that increasing the temperature at which rat hippocampal brain slices are maintained (typically from 32.5 to 38.5 degrees C) markedly inhibits excitatory synaptic transmission. This effect was reversible on cooling, readily repeatable, and was blocked by A1 receptor antagonists and by adenosine deaminase, suggesting that it was mediated by increased activation of presynaptic adenosine A1 receptors by endogenous adenosine. This increase in adenosinergic inhibition was not a response to hyperthermia per se, because it could be elicited by temperatures that remained entirely within the hypothermic range (e. g., from 32.5 to 35.5 degrees C). The increased activity at A1 receptors appeared to be attributable to the direct release of adenosine via nucleoside transporters; the release of adenine nucleotides, linked to either the activation of NMDA receptors or the increased efflux of cAMP, appeared not to be involved. These results suggest that changes in brain temperature can alter the regulation of extracellular adenosine in rat brain slices and that increased adenosine release may be an important regulatory mechanism for countering increased excitability consequent to increased brain temperature.
Indexed as
Identifiers
10066246PMC6782539W2113792847What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.