ReviewMolecular neurobiology1998
Ovarian steroids and serotonin neural function.
Review in Molecular neurobiology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Hormone therapy and cognitive function.Human reproduction updatePooled it
- Role of emotional processing in depressive responses to sex-hormone manipulation: a pharmacological fMRI study.Translational psychiatry · 2015Trial
- Facial emotion recognition and amygdala activation are associated with menstrual cycle phase.Psychoneuroendocrinology · 2008Trial
- Psychedelics and women's mental health: the effects of female sex hormones on psychedelics' efficacy and tolerability.Molecular psychiatry · 2026Review
- Estimates of persistent inward currents in lower limb motoneurons are larger in females than in males.Journal of neurophysiology · 2023Article
- A Cross-Sectional Study Examining the Association between Physical Activity and Perinatal Depression.Medicina (Kaunas, Lithuania) · 2022Article
- Review
- School-age social behavior and pragmatic language ability in children with prenatal serotonin reuptake inhibitor exposure.Development and psychopathology · 2020Article
- Serotonin and motherhood: From molecules to mood.Frontiers in neuroendocrinology · 2019Review
- Sex Hormones and Processing of Facial Expressions of Emotion: A Systematic Literature Review.Frontiers in psychology · 2018Article
- Early antipsychotic treatment in juvenile rats elicits long-term alterations to the adult serotonin receptors.Neuropsychiatric disease and treatment · 2018Article
- Effects of different add-back regimens on hypoestrogenic problems by postoperative gonadotropin-releasing hormone agonist treatment in endometriosis.Obstetrics & gynecology science · 2016Article
- Interaction of brain 5-HT synthesis deficiency, chronic stress and sex differentially impact emotional behavior in Tph2 knockout mice.Psychopharmacology · 2015Article
- Prenatal SSRI use and offspring with autism spectrum disorder or developmental delay.Pediatrics · 2014Article
- Crohn's disease in women.International journal of women's health · 2013Review
- 5-HTTLPR X stress in adolescent depression: moderation by MAOA and gender.Journal of abnormal child psychology · 2013Article
- The impact of arousal state, sex, and sleep apnea on the magnitude of progressive augmentation and ventilatory long-term facilitation.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- Association of menstrual cycle phase with the core components of empathy.Hormones and behavior · 2013Article
- Comparison of the effects of estradiol and progesterone on serotonergic function.Biological psychiatry · 2012Article
- Progesterone and Cerebral Function during Emotion Processing in Men and Women with Schizophrenia.Schizophrenia research and treatment · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The serotonin neural system originates from ten nuclei in the mid- and hindbrain regions. The cells of the rostral nuclei project to almost every area of the forebrain, including the hypothalamus, limbic regions, basal ganglia, thalamic nuclei, and cortex. The caudal nuclei project to the spinal cord and interact with numerous autonomic and sensory systems. This article reviews much of the available literature from basic research and relevant clinical research that indicates that ovarian steroid hormones, estrogens and progestins, affect the function of the serotonin neural system. Experimental results in nonhuman primates from this laboratory are contrasted with studies in rodents and humans. The sites of action of ovarian hormones on the serotonin neural system include effects within serotonin neurons as well as effects on serotonin afferent neurons and serotonin target neurons. Therefore, information on estrogen and progestin receptor-containing neurons was synthesized with information on serotonin afferent and efferent circuits. The ability of estrogens and progestins to alter the function of the serotonin neural system at various levels provides a cellular mechanism whereby ovarian hormones can impact mood, cognition, pain, and numerous other autonomic functions.
Indexed as
Identifiers
10065876What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.