ArticleThe EMBO journal1999
Encoding of Ca2+ signals by differential expression of IP3 receptor subtypes.
Article in The EMBO journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 150 papers.
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Who cites it
150 citing papers in PubMed, 389 citations in OpenAlex.
- Conformational landscape and ligand-dependent clustering of the human type 2 IPNature communications · 2026Article
- Conformational landscape and clustering of human type 2 IPbioRxiv : the preprint server for biology · 2026Article
- Therapeutic targeting of endothelial calcium signaling accelerates the resolution of lung injury.Signal transduction and targeted therapy · 2025Article
- From IP3RPEP6 Inhibition of IPCellular and molecular life sciences : CMLS · 2025Review
- Jaw1 accelerates the reaction speed of the CaScientific reports · 2025Article
- CaBiomedicines · 2025Review
- IP3R2-mediated CaCell death discovery · 2024Article
- Relevance of the endoplasmic reticulum-mitochondria axis in cancer diagnosis and therapy.Experimental & molecular medicine · 2024Review
- Cracking the Endothelial Calcium (CaInternational journal of molecular sciences · 2023Review
- Store-Operated CaJournal of clinical medicine · 2023Review
- New insights into the role of acidocalcisomes in trypanosomatids.The Journal of eukaryotic microbiology · 2022Review
- Cdk5 regulates IP3R1-mediated CaCellular and molecular life sciences : CMLS · 2022Article
- Jaw1/LRMP increases CaScientific reports · 2022Article
- Preferential Expression of CaBiomolecules · 2022Article
- Inositol (1,4,5)-Trisphosphate Receptors in Invasive Breast Cancer: A New Prognostic Tool?International journal of molecular sciences · 2022Article
- IRAG2 Interacts with IPInternational journal of molecular sciences · 2021Article
- The discovery and development of IP3 receptor modulators: an update.Expert opinion on drug discovery · 2021Article
- Inositol 1,4,5-trisphosphate 3-kinase B promotes CaScience signaling · 2021Article
- The effect of iron on the expression levels of calcium related gene in cisplatin resistant epithelial ovarian cancer cells.Exploration of targeted anti-tumor therapy · 2021Article
- Astrocytic IPFrontiers in cellular neuroscience · 2021Review
90 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inositol 1,4,5-trisphosphate (IP3) plays a key role in Ca2+ signalling, which exhibits a variety of spatio-temporal patterns that control important cell functions. Multiple subtypes of IP3 receptors (IP3R-1, -2 and -3) are expressed in a tissue- and development-specific manner and form heterotetrameric channels through which stored Ca2+ is released, but the physiological significance of the differential expression of IP3R subtypes is not known. We have studied the Ca2+-signalling mechanism in genetically engineered B cells that express either a single or a combination of IP3R subtypes, and show that Ca2+-signalling patterns depend on the IP3R subtypes, which differ significantly in their response to agonists, i.e. IP3, Ca2+ and ATP. IP3R-2 is the most sensitive to IP3 and is required for the long lasting, regular Ca2+ oscillations that occur upon activation of B-cell receptors. IP3R-1 is highly sensitive to ATP and mediates less regular Ca2+ oscillations. IP3R-3 is the least sensitive to IP3 and Ca2+, and tends to generate monophasic Ca2+ transients. Furthermore, we show for the first time functional interactions between coexpressed subtypes. Our results demonstrate that differential expression of IP3R subtypes helps to encode IP3-mediated Ca2+ signalling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.