ReviewEnvironmental health perspectives1999
Developmental pathways: Sonic hedgehog-Patched-GLI.
Review in Environmental health perspectives, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 55 citations in OpenAlex.
- Regulation of stem cell fate by HSPGs: implication in hair follicle cycling.NPJ Regenerative medicine · 2022Review
- CRISPR editing of the GLI1 first intron abrogates GLI1 expression and differentially alters lineage commitment.Stem cells (Dayton, Ohio) · 2021Article
- RKIP reduction enhances radioresistance by activating the Shh signaling pathway in non-small-cell lung cancer.OncoTargets and therapy · 2017Article
- Functional Interaction between HEXIM and Hedgehog Signaling during Drosophila Wing Development.PloS one · 2016Article
- Polo-like kinase 2 is a mediator of hedgehog survival signaling in cholangiocarcinoma.Hepatology (Baltimore, Md.) · 2013Article
- An inductive signalling network regulates mammalian tooth morphogenesis with implications for tooth regeneration.Cell proliferation · 2013Review
- High expression of Sonic Hedgehog signaling pathway genes indicates a risk of recurrence of breast carcinoma.OncoTargets and therapy · 2013Article
- A hedgehog survival pathway in 'undead' lipotoxic hepatocytes.Journal of hepatology · 2012Article
- RACK1 promotes non-small-cell lung cancer tumorigenicity through activating sonic hedgehog signaling pathway.The Journal of biological chemistry · 2012Article
- Myofibroblast-derived PDGF-BB promotes Hedgehog survival signaling in cholangiocarcinoma cells.Hepatology (Baltimore, Md.) · 2011Article
- Missense mutations in IHH impair Indian Hedgehog signaling in C3H10T1/2 cells: Implications for brachydactyly type A1, and new targets for Hedgehog signaling.Cellular & molecular biology letters · 2010Article
- Molecular signaling pathways that regulate prostate gland development.Differentiation; research in biological diversity · 2008Review
- The role of estrogens in normal and abnormal development of the prostate gland.Annals of the New York Academy of Sciences · 2006Review
- Animal models in pediatric surgery.Pediatric surgery international · 2006Review
- Differential range and activity of various forms of the Hedgehog protein.BMC developmental biology · 2005Article
- Krüppel-like zinc finger protein Gli-similar 2 (Glis2) represses transcription through interaction with C-terminal binding protein 1 (CtBP1).Nucleic acids research · 2005Article
- Molecular pathogenesis of childhood brain tumors.Journal of neuro-oncology · 2004Review
- GLIS3, a novel member of the GLIS subfamily of Krüppel-like zinc finger proteins with repressor and activation functions.Nucleic acids research · 2003Article
- Adriamycin effects on the chick embryo.Pediatric surgery international · 2003Article
- Expression pattern of Cubitus interruptus from the mulberry silkworm Bombyx mori in late developmental stages.Development genes and evolution · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Developmental pathways are networks of genes that act coordinately to establish the body plan. Disruptions of genes in one pathway can have effects in related pathways and may result in serious dysmorphogenesis or cancer. Environmental exposures can be associated with poor pregnancy outcomes, including dysmorphic offspring or children with a variety of diseases. An important goal of environmental science should be reduction of these poor outcomes. This will require an understanding of the genes affected by specific exposures and the consequence of alterations in these genes or their products, which in turn will require an understanding of the pathways critical in development. The ligand Sonic hedgehog, the receptors Patched and Smoothened, and the GLI family of transcription factors represent one such pathway. This pathway illustrates several operating principles important in the consideration of developmental consequences of environmental exposures to toxins.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.