ArticleAmerican journal of human genetics1999
Analysis of affected sib pairs, with covariates--with and without constraints.
Article in American journal of human genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- The null distribution of likelihood-ratio statistics in the conditional-logistic linkage model.Frontiers in genetics · 2013Article
- A method to detect single-nucleotide polymorphisms accounting for a linkage signal using covariate-based affected relative pair linkage analysis.BMC proceedings · 2011Article
- Incorporation of covariates in simultaneous localization of two linked loci using affected relative pairs.BMC genetics · 2010Article
- Design considerations in a sib-pair study of linkage for susceptibility loci in cancer.BMC medical genetics · 2008Article
- Testing genetic linkage with relative pairs and covariates by quasi-likelihood score statistics.Human heredity · 2007Article
- Evidence of linkage to chromosome 1 for early age of onset of rheumatoid arthritis and HLA marker DRB1 genotype in NARAC data.BMC proceedings · 2007Article
- A novel framework for sib pair linkage analysis.American journal of human genetics · 2006Article
- Corrections to the parameterization of constraints on allele sharing in sibling pairs alter covariate-parameter estimates but not sharing-probability estimates or power of tests for linkage.American journal of human genetics · 2005Article
- A genome wide search for alcoholism susceptibility genes.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2004Article
- Genetic linkage analysis of a dichotomous trait incorporating a tightly linked quantitative trait in affected sib pairs.American journal of human genetics · 2003Article
- A genome screen of systemic lupus erythematosus using affected-relative-pair linkage analysis with covariates demonstrates genetic heterogeneity.Genes and immunity · 2002Article
- Model-free linkage analysis with covariates confirms linkage of prostate cancer to chromosomes 1 and 4.American journal of human genetics · 2001Article
- A general conditional-logistic model for affected-relative-pair linkage studies.American journal of human genetics · 1999Article
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Abstract
Covariate models have previously been developed as an extension to affected-sib-pair methods in which the covariate effects are jointly estimated with the degree of excess allele sharing. These models can estimate the differences in sib-pair allele sharing that are associated with measurable environment or genes. When there are no covariates, the pattern of identical-by-descent allele sharing in affected sib pairs is expected to fall within a small triangular region of the potential parameter space, under most genetic models. By restriction of the estimated allele sharing to this triangle, improved power is obtained in tests for genetic linkage. When the affected-sib-pair model is generalized to allow for covariates that affect allele sharing, however, new constraints and new methods for the application of constraints are required. Three generalized constraint methods are proposed and evaluated by use of simulated data. The results compare the power of the different methods, with and without covariates, for a single-gene model with age-dependent onset and for quantitative and qualitative gene-environment and gene-gene interaction models. Covariates can improve the power to detect linkage and can be particularly valuable when there are qualitative gene-environment interactions. In most situations, the best strategy is to assume that there is no dominance variance and to obtain constrained estimates for covariate models under this assumption.
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