ArticleProceedings of the National Academy of Sciences of the United States of America1999
Two gonadotropin-releasing hormone receptor subtypes with distinct ligand selectivity and differential distribution in brain and pituitary in the goldfish (Carassius auratus).
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Differential involvement of cAMP/PKA-, PLC/PKC- and CaFrontiers in endocrinology · 2024Article
- Pheromone Perception in Fish: Mechanisms and Modulation by Internal Status.Integrative and comparative biology · 2023Review
- Molecular Identification, Characterization, and Expression Analysis of a Gonadotropin-Releasing Hormone Receptor (GnRH-R) in Pacific Abalone,Molecules (Basel, Switzerland) · 2020Article
- A Comparative Update on the Neuroendocrine Regulation of Growth Hormone in Vertebrates.Frontiers in endocrinology · 2020Review
- A Type IIb, but Not Type IIa, GnRH Receptor Mediates GnRH-Induced Release of Growth Hormone in the Ricefield Eel.Frontiers in endocrinology · 2018Article
- GnRH suppresses excitability of visual processing neurons in the optic tectum.Journal of neurophysiology · 2015Article
- Apoptotic death of prostate cancer cells by a gonadotropin-releasing hormone-II antagonist.PloS one · 2014Article
- Expression of three GnRH receptors in specific tissues in male and female sea lampreys Petromyzon marinus at three distinct life stages.Frontiers in neuroscience · 2013Article
- Functional significance of GnRH and kisspeptin, and their cognate receptors in teleost reproduction.Frontiers in endocrinology · 2013Article
- Molecular cloning and pharmacological characterization of two novel GnRH receptors in the lamprey (Petromyzon marinus).Endocrinology · 2012Article
- The role of the terminal nerve and GnRH in olfactory system neuromodulation.Zoological science · 2009Review
- The chicken type III GnRH receptor homologue is predominantly expressed in the pituitary, and exhibits similar ligand selectivity to the type I receptor.The Journal of endocrinology · 2009Article
- GnRH and gpcr: laser-captured single cell gene profiling.Fish physiology and biochemistry · 2005Article
- Three GnRH receptor types in laser-captured single cells of the cichlid pituitary display cellular and functional heterogeneity.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Gonadotropin-releasing hormone (GnRH): from fish to mammalian brains.Cellular and molecular neurobiology · 2002Review
- Chimaeric gonadotropin-releasing hormone (GnRH) peptides with improved affinity for the catfish (Clarias gariepinus) GnRH receptor.The Biochemical journal · 2002Article
- A novel mammalian receptor for the evolutionarily conserved type II GnRH.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Gonadotropin-releasing hormone receptor in the teleost Haplochromis burtoni: structure, location, and function.Endocrinology · 2001Article
- Three distinct types of GnRH receptor characterized in the bullfrog.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the goldfish (Carassius auratus) the two endogenous forms of gonadotropin-releasing hormone (GnRH), namely chicken GnRH II ([His5, Trp7,Tyr8]GnRH) and salmon GnRH ([Trp7,Leu8]GnRH), stimulate the release of both gonadotropins and growth hormone from the pituitary. This control is thought to occur by means of the stimulation of distinct GnRH receptors. These receptors can be distinguished on the basis of differential gonadotropin and growth hormone releasing activities of naturally occurring GnRHs and GnRHs with variant amino acids in position 8. We have cloned the cDNAs of two GnRH receptors, GfA and GfB, from goldfish brain and pituitary. Although the receptors share 71% identity, there are marked differences in their ligand selectivity. Both receptors are expressed in the pituitary but are differentially expressed in the brain, ovary, and liver. Thus we have found and cloned two full-length cDNAs that appear to correspond to different forms of GnRH receptor, with distinct pharmacological characteristics and tissue distribution, in a single species.
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