ArticleProceedings of the National Academy of Sciences of the United States of America1999
Growth factor-mediated Fyn signaling regulates alpha-amino-3- hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor expression in rodent neocortical neurons.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 65 citations in OpenAlex.
- Fyn Kinase in Alzheimer's Disease: Unraveling Molecular Mechanisms and Therapeutic Implications.Molecular neurobiology · 2025Review
- Thiazole Derivatives as Modulators of GluA2 AMPA Receptors: Potent Allosteric Effects and Neuroprotective Potential.Biomolecules · 2023Article
- Secreted Amyloid Precursor Protein-Alpha Enhances LTP Through the Synthesis and Trafficking of CaFrontiers in molecular neuroscience · 2021Article
- Src Family Kinases in the Central Nervous System: Their Emerging Role in Pathophysiology of Migraine and Neuropathic Pain.Current neuropharmacology · 2021Article
- Glutamatergic neurotransmission in the prefrontal cortex mediates the suppressive effect of intra-prelimbic cortical infusion of BDNF on cocaine-seeking.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2016Article
- Brain-derived neurotrophic factor in urinary continence and incontinence.Nature reviews. Urology · 2014Review
- Infralimbic BDNF/TrkB enhancement of GluN2B currents facilitates extinction of a cocaine-conditioned place preference.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- BDNF contributes to both rapid and homeostatic alterations in AMPA receptor surface expression in nucleus accumbens medium spiny neurons.The European journal of neuroscience · 2014Article
- Acute BDNF treatment upregulates GluR1-SAP97 and GluR2-GRIP1 interactions: implications for sustained AMPA receptor expression.PloS one · 2013Article
- Gliomas and seizures.Medical hypotheses · 2012Article
- Tyrosine phosphorylation of the human serotonin transporter: a role in the transporter stability and function.Molecular pharmacology · 2012Article
- Brain-derived neurotrophic factor-tyrosine kinase B pathway mediates NMDA receptor NR2B subunit phosphorylation in the supraoptic nuclei following progressive dehydration.Journal of neuroendocrinology · 2011Article
- A peptide mimetic targeting trans-homophilic NCAM binding sites promotes spatial learning and neural plasticity in the hippocampus.PloS one · 2011Article
- Protein tyrosine kinase involvement in learning-produced changes in Hermissenda type B photoreceptors.Journal of neurophysiology · 2009Article
- Positive AMPA receptor modulation rapidly stimulates BDNF release and increases dendritic mRNA translation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- PTPepsilon has a critical role in signaling transduction pathways and phosphoprotein network topology in red cells.Proteomics · 2008Article
- Potential molecular mechanism for c-Src kinase-mediated regulation of intestinal cell migration.The Journal of biological chemistry · 2008Article
- Role of the brain-derived neurotrophic factor at glutamatergic synapses.British journal of pharmacology · 2008Review
- Transforming growth factor alpha attenuates the functional expression of AMPA receptors in cortical GABAergic neurons.Molecular and cellular neurosciences · 2006Article
- Absence of Fyn and Src causes a reeler-like phenotype.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Src-family protein tyrosine kinases (PTKs) transduce signals to regulate neuronal development and synaptic plasticity. However, the nature of their activators and molecular mechanisms underlying these neural processes are unknown. Here, we show that brain-derived neurotrophic factor (BDNF) and platelet-derived growth factor enhance expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptor 1 and 2/3 proteins in rodent neocortical neurons via the Src-family PTK(s). The increase in AMPA receptor levels was blocked in cultured neocortical neurons by addition of a Src-family-selective PTK inhibitor. Accordingly, neocortical cultures from Fyn-knockout mice failed to respond to BDNF whereas those from wild-type mice responded. Moreover, the neocortex of young Fyn mutants exhibited a significant in vivo reduction in these AMPA receptor proteins but not in their mRNA levels. In vitro kinase assay revealed that BDNF can indeed activate the Fyn kinase: It enhanced tyrosine phosphorylation of Fyn as well as that of enolase supplemented exogenously. All of these results suggest that the Src-family kinase Fyn, activated by the growth factors, plays a crucial role in modulating AMPA receptor expression during brain development.
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