ArticleProceedings of the National Academy of Sciences of the United States of America1999
Dopamine receptor subtypes modulate olfactory bulb gamma-aminobutyric acid type A receptors.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 80 citations in OpenAlex.
- Carbonic anhydrase I, II, and VI, blood plasma, erythrocyte and saliva zinc and copper increase after repetitive transcranial magnetic stimulation.The American journal of the medical sciences · 2010Trial
- Differential dopaminergic modulation of the antennal lobe of Drosophila melanogaster.Communications biology · 2025Article
- D2 receptor activation modulates NMDA receptor antagonist-enhanced high-frequency oscillations in the olfactory bulb of freely moving rats.Psychopharmacology · 2025Article
- Dynamic developmental changes in neurotransmitters supporting infant attachment learning.Neuroscience and biobehavioral reviews · 2023Review
- Repeated inhibition of sigma-1 receptor suppresses GABAFrontiers in molecular neuroscience · 2022Article
- Interaction of clozapine with metformin in a schizophrenia rat model.Scientific reports · 2021Article
- Characterization of the Functional Cross-Talk between Surface GABAInternational journal of molecular sciences · 2021Article
- The voltage-gated potassium channel Shaker promotes sleep via thermosensitive GABA transmission.Communications biology · 2020Article
- Illuminating and Sniffing Out the Neuromodulatory Roles of Dopamine in the Retina and Olfactory Bulb.Frontiers in cellular neuroscience · 2020Review
- Dopaminergic modulation of olfactory-evoked motor output in sea lampreys (Petromyzon marinus L.).The Journal of comparative neurology · 2020Article
- Partial depletion of dopaminergic neurons in the substantia nigra impairs olfaction and alters neural activity in the olfactory bulb.Scientific reports · 2019Article
- The Neuropeptide Orexin-A Inhibits the GABAJournal of molecular neuroscience : MN · 2017Article
- Drug-induced Parkinson's disease modulates protein kinase A and Olfactory Marker Protein in the mouse olfactory bulb.Behavioral and brain functions : BBF · 2017Article
- Differential regulation of synaptic and extrasynaptic α4 GABA(A) receptor populations by protein kinase A and protein kinase C in cultured cortical neurons.Neuropharmacology · 2016Article
- Olfactory impairment in the rotenone model of Parkinson's disease is associated with bulbar dopaminergic D2 activity after REM sleep deprivation.Frontiers in cellular neuroscience · 2014Article
- Metabotropic regulation of extrasynaptic GABAA receptors.Frontiers in neural circuits · 2013Review
- Dopaminergic modulation of mitral cells and odor responses in the zebrafish olfactory bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- GABA(A) Receptors: Post-Synaptic Co-Localization and Cross-Talk with Other Receptors.Frontiers in cellular neuroscience · 2011Article
- Somatostatin contributes to in vivo gamma oscillation modulation and odor discrimination in the olfactory bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Olfactory oscillations: the what, how and what for.Trends in neurosciences · 2009Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gamma-aminobutyric acid type A (GABAA) receptor is the predominant Cl- channel protein mediating inhibition in the olfactory bulb and elsewhere in the mammalian brain. The olfactory bulb is rich in neurons containing both GABA and dopamine. Dopamine D1 and D2 receptors are also highly expressed in this brain region with a distinct and complementary distribution pattern. This distribution suggests that dopamine may control the GABAergic inhibitory processing of odor signals, possibly via different signal-transduction mechanisms. We have observed that GABAA receptors in the rat olfactory bulb are differentially modulated by dopamine in a cell-specific manner. Dopamine reduced the currents through GABA-gated Cl- channels in the interneurons, presumably granule cells. This action was mediated via D1 receptors and involved phosphorylation of GABAA receptors by protein kinase A. Enhancement of GABA responses via activation of D2 dopamine receptors and phosphorylation of GABAA receptors by protein kinase C was observed in mitral/tufted cells. Decreasing or increasing the binding affinity for GABA appears to underlie the modulatory effects of dopamine via distinct receptor subtypes. This dual action of dopamine on inhibitory GABAA receptor function in the rat olfactory bulb could be instrumental in odor detection and discrimination, olfactory learning, and ultimately odotopic memory formation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.