ArticleProceedings of the National Academy of Sciences of the United States of America1999
A binding site for homeodomain and Pax proteins is necessary for L1 cell adhesion molecule gene expression by Pax-6 and bone morphogenetic proteins.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 102 citations in OpenAlex.
- A cis-element in the Notch1 locus is involved in the regulation of gene expression in interneuron progenitors.Developmental biology · 2012Article
- Cell migration in Drosophila optic lobe neurons is controlled by eyeless/Pax6.Development (Cambridge, England) · 2011Article
- Article
- Role of the cytoplasmic domain of the L1 cell adhesion molecule in brain development.The Journal of comparative neurology · 2010Article
- Nuclear factor I-A represses expression of the cell adhesion molecule L1.BMC molecular biology · 2009Article
- Eye and neural defects associated with loss of GDF6.BMC developmental biology · 2006Article
- Crystallization and preliminary X-ray analysis of the Pax6 paired domain bound to the Pax6 gene enhancer.Acta crystallographica. Section F, Structural biology and crystallization communications · 2005Article
- Role of Fabp7, a downstream gene of Pax6, in the maintenance of neuroepithelial cells during early embryonic development of the rat cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Hox genes and their candidate downstream targets in the developing central nervous system.Cellular and molecular neurobiology · 2005Review
- L1, a novel target of beta-catenin signaling, transforms cells and is expressed at the invasive front of colon cancers.The Journal of cell biology · 2005Article
- Expression profiles suggest a role for Pax7 in the establishment of tectal polarity and map refinement.Experimental brain research · 2004Article
- The C264Y missense mutation in the extracellular domain of L1 impairs protein trafficking in vitro and in vivo.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- A comparative cDNA microarray analysis reveals a spectrum of genes regulated by Pax6 in mouse lens.Genes to cells : devoted to molecular & cellular mechanisms · 2002Article
- Novel PAX6 binding sites in the human genome and the role of repetitive elements in the evolution of gene regulation.Genome research · 2002Article
- Neural stem cell heterogeneity demonstrated by molecular phenotyping of clonal neurospheres.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Disruption of early events in thalamocortical tract formation in mice lacking the transcription factors Pax6 or Foxg1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Identification of differentially expressed genes in mouse Pax6 heterozygous lenses.Investigative ophthalmology & visual science · 2002Article
- Primary defects in the lens underlie complex anterior segment abnormalities of the Pax6 heterozygous eye.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Defect of tyrosine hydroxylase-immunoreactive neurons in the brains of mice lacking the transcription factor Pax6.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Synthetic promoter elements obtained by nucleotide sequence variation and selection for activity.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The cell adhesion molecule L1 regulates axonal guidance and fasciculation during development. We previously identified the regulatory region of the L1 gene and showed that it was sufficient for establishing the neural pattern of L1 expression in transgenic mice. In the present study, we characterize a DNA element within this region called the HPD that contains binding motifs for both homeodomain and Pax proteins and responds to signals from bone morphogenetic proteins (BMPs). An ATTA sequence within the core of the HPD was required for binding to the homeodomain protein Barx2 while a separate paired domain recognition motif was necessary for binding to Pax-6. In cellular transfection experiments, L1-luciferase reporter constructs containing the HPD were activated an average of 4-fold by Pax-6 in N2A cells and 5-fold by BMP-2 and BMP-4 in Ng108 cells. Both of these responses were eliminated on deletion of the HPD from L1 constructs. In transgenic mice, deletion of the HPD from an L1-lacZ reporter resulted in a loss of beta-galactosidase expression in the telencephalon and mesencephalon. Collectively, our experiments indicate that the HPD regulates L1 expression in neural tissues via homeodomain and Pax proteins and is likely to be a target of BMP signaling during development.
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