ArticleProceedings of the National Academy of Sciences of the United States of America1999
Crossreactive recognition of viral, self, and bacterial peptide ligands by human class I-restricted cytotoxic T lymphocyte clonotypes: implications for molecular mimicry in autoimmune disease.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 71 citations in OpenAlex.
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- Herpesvirus infections and post-COVID-19 manifestations: a pilot observational study.Rheumatology international · 2022Observational
- Investigation of Long COVID Prevalence and Its Relationship to Epstein-Barr Virus Reactivation.Pathogens (Basel, Switzerland) · 2021Article
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- Tetramer-Based Enrichment of Preexisting Anti-AAV8 CD8Frontiers in immunology · 2019Article
- Staphylococcus aureus Colonization: Modulation of Host Immune Response and Impact on Human Vaccine Design.Frontiers in immunology · 2014Review
- Mechanism of cellular rejection in transplantation.Pediatric nephrology (Berlin, Germany) · 2010Review
- Inducing efficient cross-priming using antigen-coated yeast particles.Journal of immunotherapy (Hagerstown, Md. : 1997) · 2008Article
- Human T lymphocyte responses against lung cancer induced by recombinant truncated mouse EGFR.Cancer immunology, immunotherapy : CII · 2006Article
- Cross-reactive influenza virus-specific CD8+ T cells contribute to lymphoproliferation in Epstein-Barr virus-associated infectious mononucleosis.The Journal of clinical investigation · 2005Article
- Cross-reactive cytotoxic T lymphocytes against human immunodeficiency virus type 1 protease and gamma interferon-inducible protein 30.Journal of virology · 2005Article
- Ex vivo generation of genetically modified dendritic cells for immunotherapy: implications of lymphocyte contamination.Gene therapy · 2005Article
- Multiple T-cell clones specific for the same foreign pMHC ligand can be generated from a single, ancestral TCR-VDJbeta precursor.Immunologic research · 2004Article
- Plasticity of T cell memory responses to viruses.Immunity · 2004Review
- Decreased expression of the CD3zeta chain in T cells infiltrating the synovial membrane of patients with osteoarthritis.Clinical and diagnostic laboratory immunology · 2004Article
- Detection and characterization of cellular immune responses using peptide-MHC microarrays.PLoS biology · 2003Article
- Mimicry between the hepatitis C virus polyprotein and antigenic targets of nuclear and smooth muscle antibodies in chronic hepatitis C virus infection.Clinical and experimental immunology · 2003Article
- Human papillomavirus type 16 E7 peptide-directed CD8+ T cells from patients with cervical cancer are cross-reactive with the coronavirus NS2 protein.Journal of virology · 2003Article
- Altered CD8+ T cell responses to selected Epstein-Barr virus immunodominant epitopes in patients with multiple sclerosis.Clinical and experimental immunology · 2003Article
- The immunology of Epstein-Barr virus infection.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2001Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The immunodominant, CD8(+) cytotoxic T lymphocyte (CTL) response to the HLA-B8-restricted peptide, RAKFKQLL, located in the Epstein-Barr virus immediate-early antigen, BZLF1, is characterized by a diverse T cell receptor (TCR) repertoire. Here, we show that this diversity can be partitioned on the basis of crossreactive cytotoxicity patterns involving the recognition of a self peptide-RSKFRQIV-located in a serine/threonine kinase and a bacterial peptide-RRKYKQII-located in Staphylococcus aureus replication initiation protein. Thus CTL clones that recognized the viral, self, and bacterial peptides expressed a highly restricted alphabeta TCR phenotype. The CTL clones that recognized viral and self peptides were more oligoclonal, whereas clones that strictly recognized the viral peptide displayed a diverse TCR profile. Interestingly, the self and bacterial peptides equally were substantially less effective than the cognate viral peptide in sensitizing target cell lysis, and also resulted only in a weak reactivation of memory CTLs in limiting dilution assays, whereas the cognate peptide was highly immunogenic. The described crossreactions show that human antiviral, CD8(+) CTL responses can be shaped by peptide ligands derived from autoantigens and environmental bacterial antigens, thereby providing a firm structural basis for molecular mimicry involving class I-restricted CTLs in the pathogenesis of autoimmune disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.