ArticleProceedings of the National Academy of Sciences of the United States of America1999
The cellular ecology of progressive neoplastic transformation: a clonal analysis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Cell-cell contact interactions conditionally determine suppression and selection of the neoplastic phenotype.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Selective clonal expansion and microenvironmental permissiveness in tobacco carcinogenesis.Oncogene · 2002Review
- A growth-constrained environment drives tumor progression invivo.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- It takes a tissue to make a tumor: epigenetics, cancer and the microenvironment.Journal of mammary gland biology and neoplasia · 2001Review
- Coculturing diverse clonal populations prevents the early-stage neoplastic progression that occurs in the separate clones.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Clonal dynamics of progressive neoplastic transformation.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A comparison was made of the competence for neoplastic transformation in three different sublines of NIH 3T3 cells and multiple clonal derivatives of each. Over 90% of the neoplastic foci produced by an uncloned transformed (t-SA') subline on a confluent background of nontransformed cells were of the dense, multilayered type, but about half of the t-SA' clones produced only light foci in assays without background. This asymmetry apparently arose from the failure of the light focus formers to register on a background of nontransformed cells. Comparison was made of the capacity for confluence-mediated transformation between uncloned parental cultures and their clonal derivatives by using two nontransformed sublines, one of which was highly sensitive and the other relatively refractory to confluence-mediated transformation. Transformation was more frequent in the clones than in the uncloned parental cultures for both sublines. This was dramatically so in the refractory subline, where the uncloned culture showed no overt sign of transformation in serially repeated assays but increasing numbers of its clones exhibited progressive transformation. The reason for the greater susceptibility of the pure clones is apparently the suppression of transformation among the diverse membership that makes up the uncloned parental culture. Progressive selection toward increasing degrees of transformation in confluent cultures plays a major role in the development of dense focus formers, but direct induction by the constraint of confluence may contribute by heritably damaging cells. In view of our finding of increased susceptibility to transformation in clonal versus uncloned populations, expansion of some clones at the expense of others during the aging process would contribute to the marked increase of cancer with age.
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