ArticleProceedings of the National Academy of Sciences of the United States of America1999
Thyroid hormone receptor-associated proteins and general positive cofactors mediate thyroid hormone receptor function in the absence of the TATA box-binding protein-associated factors of TFIID.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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50 citing papers in PubMed, 166 citations in OpenAlex.
- Transcriptional Cofactors for Thyroid Hormone Receptors.Endocrinology · 2025Review
- An IDR-dependent mechanism for nuclear receptor control of Mediator interaction with RNA polymerase II.Molecular cell · 2024Article
- Exploitation of the Mediator complex by viruses.PLoS pathogens · 2022Article
- Thyroid hormone receptor β sumoylation is required for thyrotropin regulation and thyroid hormone production.JCI insight · 2021Article
- Molecular Functions of Thyroid Hormone Signaling in Regulation of Cancer Progression and Anti-Apoptosis.International journal of molecular sciences · 2019Review
- Regulation of cardiac transcription by thyroid hormone and Med13.Journal of molecular and cellular cardiology · 2019Article
- Mutations in TBL1X Are Associated With Central Hypothyroidism.The Journal of clinical endocrinology and metabolism · 2016Observational
- Thrap3 docks on phosphoserine 273 of PPARγ and controls diabetic gene programming.Genes & development · 2014Article
- The syndromes of reduced sensitivity to thyroid hormone.Biochimica et biophysica acta · 2013Review
- Article
- General molecular biology and architecture of nuclear receptors.Current topics in medicinal chemistry · 2012Review
- Origins and activity of the Mediator complex.Seminars in cell & developmental biology · 2011Review
- The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation.Nature reviews. Genetics · 2010Review
- Article
- Negative regulation of TSHalpha target gene by thyroid hormone involves histone acetylation and corepressor complex dissociation.Molecular endocrinology (Baltimore, Md.) · 2009Article
- Mediator structural conservation and implications for the regulation mechanism.Structure (London, England : 1993) · 2009Article
- MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation.The EMBO journal · 2007Article
- CDK8 is a stimulus-specific positive coregulator of p53 target genes.Molecular cell · 2007Article
- Quantitative proteomic analysis of distinct mammalian Mediator complexes using normalized spectral abundance factors.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Coactivator cross-talk specifies transcriptional output.Genes & development · 2006Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coactivators previously implicated in ligand-dependent activation functions by thyroid hormone receptor (TR) include p300 and CREB-binding protein (CBP), the steroid receptor coactivator-1 (SRC-1)-related family of proteins, and the multicomponent TR-associated protein (TRAP) complex. Here we show that two positive cofactors (PC2 and PC4) derived from the upstream stimulatory activity (USA) cofactor fraction act synergistically to mediate thyroid hormone (T3)-dependent activation either by TR or by a TR-TRAP complex in an in vitro system reconstituted with purified factors and DNA templates. Significantly, the TRAP-mediated enhancement of activation by TR does not require the TATA box-binding protein-associated factors of TFIID. Furthermore, neither the pleiotropic coactivators CBP and p300 nor members of the SRC-1 family were detected in either the TR-TRAP complex or the other components of the in vitro assay system. These results show that activation by TR at the level of naked DNA templates is enhanced by cooperative functions of the TRAP coactivators and the general coactivators PC2 and PC4, and they further indicate a potential functional redundancy between TRAPs and TATA box-binding protein-associated factors in TFIID. In conjunction with earlier studies on other nuclear receptor-interacting cofactors, the present study also suggests a multistep pathway, involving distinct sets of cofactors, for activation of hormone responsive genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.