Evidence map›Paper›PMID 10051438›Full record

ArticleThe Biochemical journal1999

Activation of integrin-beta3-associated syk in platelets.

S Sarkar, M M Rooney, S T Lord

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in The Biochemical journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 15 citations in OpenAlex.

  1. Cancer development, progression, and therapy: an epigenetic overview.International journal of molecular sciences · 2013
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

S SarkarDepartment of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.
M M Rooney
S T Lord
University of North Carolina at Chapel Hill · US

Funding

THE ROLE OF RAP1 IN INTEGRIN ACTIVATION AND PLATELET SIGNALINGP01HL045100 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PARISE, LESLIE V. · 1993 to 2007
$13.7M
ENVIRONMENTAL PATHOLOGYT32ES007017 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAUFMAN, DAVID G. · 1985 to 2011
$5.1M
MUTAGENIC STUDIES OF FIBRINOGEN ALPHA CHAIN FUNCTIONR01HL031048 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LORD, SUSAN T · 1987 to 2010
$3.5M
NHLBI NIH HHS HL 45100NHLBI NIH HHS R01 HL31048NIEHS NIH HHS 5-T32-ESO 7017-22
6 · The paper itself

Abstract

Published data suggest that the tyrosine kinase syk participates in platelet signalling through the integrin alphaIIbbeta3. Our data show an association of syk and integrin beta3 in immunoprecipitates from unstimulated and stimulated platelets. We detected syk in anti-beta3 precipitates and, conversely, beta3 in anti-syk precipitates. In vitro kinase assays with anti-beta3 precipitates demonstrated that syk activity was enhanced in ADP-stimulated platelets.

Indexed as

Antigens, CDBlood PlateletsEnzyme ActivationEnzyme PrecursorsHumansIntegrin beta3Intracellular Signaling Peptides and ProteinsIn Vitro TechniquesPhosphorylationPlatelet Membrane GlycoproteinsPrecipitin TestsProtein-Tyrosine KinasesSyk KinaseAntigens, CDEnzyme PrecursorsIntegrin beta3Intracellular Signaling Peptides and ProteinsPlatelet Membrane GlycoproteinsProtein-Tyrosine KinasesSyk KinaseSYK protein, human

Identifiers

PMID10051438
PMCPMC1220102
OpenAlexW2023551361

What OpenQuestion holds

Texttitle and abstract
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.