ArticleBritish journal of pharmacology1999
Effects of Ca2+ concentration and Ca2+ channel blockers on noradrenaline release and purinergic neuroeffector transmission in rat tail artery.
Article in British journal of pharmacology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 54 citations in OpenAlex.
- Purinoceptor: a novel target for hypertension.Purinergic signalling · 2023Review
- The Pharmacological Effects of Phenylephrine are Indirect, Mediated by Noradrenaline Release from the Cytoplasm.Neurochemical research · 2022Article
- Chloride Ions, Vascular Function and Hypertension.Biomedicines · 2022Review
- Role of the sympathetic autonomic nervous system in hypoxic remodeling of the fetal cerebral vasculature.Journal of cardiovascular pharmacology · 2015Review
- The purinergic neurotransmitter revisited: a single substance or multiple players?Pharmacology & therapeutics · 2014Review
- Article
- Stargazin-related protein γ₇ is associated with signalling endosomes in superior cervical ganglion neurons and modulates neurite outgrowth.Journal of cell science · 2011Article
- Beta-subunits promote the expression of Ca(V)2.2 channels by reducing their proteasomal degradation.The Journal of biological chemistry · 2011Article
- Antioxidant treatment restores prejunctional regulation of purinergic transmission in mesenteric arteries of deoxycorticosterone acetate-salt hypertensive rats.Neuroscience · 2010Article
- Storage and secretion of beta-NAD, ATP and dopamine in NGF-differentiated rat pheochromocytoma PC12 cells.The European journal of neuroscience · 2009Article
- Tumour necrosis factor alpha activates nuclear factor kappaB signalling to reduce N-type voltage-gated Ca2+ current in postganglionic sympathetic neurons.The Journal of physiology · 2009Article
- N-type and P/Q-type calcium channels regulate differentially the release of noradrenaline, ATP and beta-NAD in blood vessels.Neuropharmacology · 2009Article
- P2X(7) Receptors in Neurological and Cardiovascular Disorders.Cardiovascular psychiatry and neurology · 2009Article
- ATP is the predominant sympathetic neurotransmitter in rat mesenteric arteries at high pressure.The Journal of physiology · 2007Article
- Cilnidipine, a slow-acting Ca2+ channel blocker, induces relaxation in porcine coronary artery: role of endothelial nitric oxide and [Ca2+]i.British journal of pharmacology · 2006Article
- Selective release of ATP from sympathetic nerves of rat vas deferens by the toxin TsTX-I from Brazilian scorpion Tityus serrulatus.British journal of pharmacology · 2005Article
- Selective modulation of noradrenaline release by alpha 2-adrenoceptor blockade in the rat-tail artery in vitro.British journal of pharmacology · 2004Article
- Differential involvement of N-type calcium channels in transmitter release from vasoconstrictor and vasodilator neurons.British journal of pharmacology · 2004Article
- Neurotransmitter release mechanisms in sympathetic neurons: past, present, and future perspectives.Neurochemical research · 2001Review
- Enhancement of ATP release in hindlimb sympathetic perivascular nerve of the golden hamster during hibernation.The Journal of physiology · 2001Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The effects of Ca2+ concentration and Ca2+ channel blockers on noradrenaline (NA) and adenosine 5'-triphosphate (ATP) release from postganglionic sympathetic nerves have been investigated in rat tail arteries in vitro. Intracellularly recorded excitatory junction potentials (e.j.ps) were used as a measure of ATP release and continuous amperometry was used to measure NA release. 2. Varying the extracellular Ca2+ concentration similarly affected the amplitudes of e.j.ps and NA-induced oxidation currents evoked by trains of ten stimuli at 1 Hz. 3. The N-type Ca2+ blocker, omega-conotoxin GVIA (omega-CTX GVIA, 0.1 microM) reduced the amplitudes of both e.j.ps (evoked by trains of ten stimuli at 1 Hz) and NA-induced oxidation currents (evoked by trains of ten stimuli at 1 Hz and 50 stimuli at 10 Hz) by about 90%. 4. The omega-CTX GVIA resistant e.j.ps and NA-induced oxidation currents evoked by trains of 50 stimuli at 10 Hz were abolished by the non-selective Ca2+ channel blocker, Cd2+ (0.1 mM), and were reduced by omega-conotoxin MVIIC (0.5 microM) and omega-agatoxin IVA (40 nM). 5. Nifedipine (10 microm) had no inhibitory effect on omega-CTX GVIA resistant e.j.ps and NA-induced oxidation currents. 6. Thus both varying Ca2+ concentration and applying Ca2+ channel blockers results in similar effects on NA and ATP release from postganglionic sympathetic nerves. These findings are consistent with the hypothesis that NA and ATP are co-released together from the sympathetic nerve terminals.
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