ArticleThe Journal of physiology1999
Confocal calcium imaging reveals an ionotropic P2 nucleotide receptor in the paranodal membrane of rat Schwann cells.
Article in The Journal of physiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 44 citations in OpenAlex.
- Functional P2XThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Up-regulation of P2X7 receptors mediating proliferation of Schwann cells after sciatic nerve injury.Purinergic signalling · 2015Article
- The role of oxidative stress in degeneration of the neuromuscular junction in amyotrophic lateral sclerosis.Frontiers in cellular neuroscience · 2014Review
- P2X7 purinoceptors contribute to the death of Schwann cells transplanted into the spinal cord.Cell death & disease · 2013Article
- Article
- Neuronal activity in the hub of extrasynaptic Schwann cell-axon interactions.Frontiers in cellular neuroscience · 2013Article
- Purinergic trophic signalling in glial cells: functional effects and modulation of cell proliferation, differentiation, and death.Purinergic signalling · 2012Review
- Perisynaptic glia discriminate patterns of motor nerve activity and influence plasticity at the neuromuscular junction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- P2X7-mediated increased intracellular calcium causes functional derangement in Schwann cells from rats with CMT1A neuropathy.The Journal of biological chemistry · 2009Article
- Purinergic modulation of synaptic signalling at the neuromuscular junction.Pflugers Archiv : European journal of physiology · 2006Review
- P2X(7) nucleotide receptors mediate caspase-8/9/3-dependent apoptosis in rat primary cortical neurons.Purinergic signalling · 2005Article
- Ionic currents in isolated and in situ squid Schwann cells.The Journal of physiology · 2002Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The paranodal Schwann cell region is of major importance for the function of a myelinated axon. In the present study we searched for a possible ionotropic effect of extracellular ATP in this Schwann cell compartment. 2. Whole-cell patch-clamp recordings from cultured rat Schwann cells revealed that ATP and 2'-3'-O-(4-benzoylbenzoyl)-adenosine 5'-triphosphate (BzATP) induced a non-specific cation current. The effect of ATP was much enhanced in a Ca2+- and Mg2+-free solution. ADP, UTP and alpha,beta-methylene adenosine 5'-triphosphate (alpha,beta-meATP) had no effect. 3. Confocal Ca2+ imaging of myelinating Schwann cells in isolated rat spinal roots showed a BzATP-induced rise in the free intracellular Ca2+ concentration in the paranodal Schwann cell cytoplasm whereas alpha,beta-meATP and 2-(methylthio)-adenosine 5'-triphosphate were without effect. In contrast to the known metabotropic effect of UTP on these Schwann cell regions, the BzATP-induced Ca2+ signal was not transient, was unaffected by depletion of intracellular Ca2+ stores and dependent on the presence of extracellular Ca2+. 4. These results suggest that an ionotropic ATP receptor with electrophysiological and pharmacological characteristics of the P2X7 subtype of nucleotide receptors is functionally active in myelinating Schwann cells of peripheral nerves. Such a receptor might contribute to Schwann cell reactions in nerve injury or neuropathy.
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