ArticleThe Journal of experimental medicine1999
Lymph node germinal centers form in the absence of follicular dendritic cell networks.
Article in The Journal of experimental medicine, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- T Follicular Helper-Like Cells in Inflamed Non-Lymphoid Tissues.Frontiers in immunology · 2018Review
- Follicular dendritic cell disruption as a novel mechanism of virus-induced immunosuppression.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Follicular dendritic cells help establish follicle identity and promote B cell retention in germinal centers.The Journal of experimental medicine · 2011Article
- Role of macrophage migration inhibitory factor in the Th2 immune response to epicutaneous sensitization.Journal of clinical immunology · 2011Article
- Omental milky spots develop in the absence of lymphoid tissue-inducer cells and support B and T cell responses to peritoneal antigens.Immunity · 2009Article
- The absence of cutaneous lymph nodes results in a Th2 response and increased susceptibility to Leishmania major infection in mice.Infection and immunity · 2008Article
- B-cell involvement in the pathogenesis of RA-is there a contribution of the sympathetic nervous system?Immunologic research · 2008Review
- Demethylation of a specific hypersensitive site in the Th2 locus control region.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Germinal-center organization and cellular dynamics.Immunity · 2007Review
- Role of lymphotoxin in experimental models of infectious diseases: potential benefits and risks of a therapeutic inhibition of the lymphotoxin-beta receptor pathway.Infection and immunity · 2005Review
- Identification and characterization of a novel nasopharyngeal carcinoma-associated peptide: NAP-1.Journal of translational medicine · 2004Article
- Review
- Normal B cell homeostasis requires B cell activation factor production by radiation-resistant cells.The Journal of experimental medicine · 2003Article
- Manipulation of lymphoid microenvironments in nonhuman primates by an inhibitor of the lymphotoxin pathway.The Journal of clinical investigation · 2002Article
- Essential role of lymph nodes in contact hypersensitivity revealed in lymphotoxin-alpha-deficient mice.The Journal of experimental medicine · 2001Article
- Conditional vascular cell adhesion molecule 1 deletion in mice: impaired lymphocyte migration to bone marrow.The Journal of experimental medicine · 2001Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Follicular dendritic cell networks are said to be pivotal to both the formation of germinal centers (GCs) and their functions in generating antigen-specific antibody affinity maturation and B cell memory. We report that lymphotoxin beta-deficient mice form GC cell clusters in the gross anatomical location expected of GCs, despite the complete absence of follicular dendritic cell networks. Furthermore, antigen-specific GC generation was at first relatively normal, but these GCs then rapidly regressed and GC-phase antibody affinity maturation was reduced. Lymphotoxin beta-deficient mice also showed substantial B cell memory in their mesenteric lymph nodes. This memory antibody response was of relatively low affinity for antigen at week 4 after challenge, but by week 10 after challenge was comparable to wild-type, indicating that affinity maturation had failed in the GC phase but developed later.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.