ArticleBiophysical journal1999
Adhesion energy of receptor-mediated interaction measured by elastic deformation.
Article in Biophysical journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 67 citations in OpenAlex.
- Polymeric and Polymer-Functionalized Drug Delivery Vectors: From Molecular Architecture and Elasticity to Cellular Uptake.Polymers · 2025Review
- Adhesion-driven vesicle translocation through membrane-covered pores.Biophysical journal · 2025Article
- Role of Cell Adhesion in Cancer Metastasis Formation: A Review.ACS omega · 2025Review
- Size compatibility and concentration dependent supramolecular host-guest interactions at interfaces.Nature communications · 2022Article
- Sequence-defined positioning of amine and amide residues to control catechol driven wet adhesion.Chemical science · 2020Article
- Radial profile detection of multiple spherical particles in contact with interacting surfaces.PloS one · 2019Article
- Nano- and microparticles at fluid and biological interfaces.Journal of physics. Condensed matter : an Institute of Physics journal · 2017Article
- Hydrogel Microparticles as Sensors for Specific Adhesion: Case Studies on Antibody Detection and Soil Release Polymers.Gels (Basel, Switzerland) · 2017Article
- Regulation of Active ICAM-4 on Normal and Sickle Cell Disease RBCs via AKAPs Is Revealed by AFM.Biophysical journal · 2017Article
- A spatial model for integrin clustering as a result of feedback between integrin activation and integrin binding.Biophysical journal · 2012Article
- Biomechanics and biophysics of cancer cells.Acta biomaterialia · 2007Review
- Coalescence of membrane tethers: experiments, theory, and applications.Biophysical journal · 2005Article
- Molecular basis for the dynamic strength of the integrin alpha4beta1/VCAM-1 interaction.Biophysical journal · 2004Article
- Enforced detachment of red blood cells adhering to surfaces: statics and dynamics.Biophysical journal · 2004Article
- Capsule-substrate contact deformation: determination of adhesion energy.Medical & biological engineering & computing · 2002Article
- Combining constitutive materials modeling with atomic force microscopy to understand the mechanical properties of living cells.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Contact mechanics of a thin-walled capsule adhered onto a rigid planar substrate.Medical & biological engineering & computing · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
We investigated the role of receptor binding affinity in surface adhesion. A sensitive technique was developed to measure the surface energy of receptor-mediated adhesion. The experimental system involved a functionalized elastic agarose bead resting on a functionalized glass coverslip. Attractive intersurface forces pulled the two surfaces together, deforming the bead to produce an enlarged contact area. The Johnson-Kendall-Roberts (JKR) model was used to relate the surface energy of the interaction to the elasticity of the bead and the area of contact. The surface energies for different combinations of modified surfaces in solution were obtained from reflection interference contrast microscopy (RICM) measurements of the contact area formed by the bead and the coverslip. Studies with surfaces functionalized with ligand-receptor pairs showed that the relationship between surface energy and the association constant of the ligand binding has two regimes. At low binding affinity, surface energy increased linearly with the association constant, while surface energy increased logarithmically with the association constant in the high affinity regime.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.