ArticleProtein science : a publication of the Protein Society1999
Is human thioredoxin monomeric or dimeric?
Article in Protein science : a publication of the Protein Society, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 19 citations in OpenAlex.
- Structural Mechanisms of Mutant Huntingtin Aggregation Suppression by the Synthetic Chaperonin-like CCT5 Complex Explained by Cryoelectron Tomography.The Journal of biological chemistry · 2015Article
- Crystallographic studies evidencing the high energy tolerance to disrupting the interface disulfide bond of thioredoxin 1 from white leg shrimp Litopenaeus vannamei.Molecules (Basel, Switzerland) · 2014Article
- A novel and simple method of production and biophysical characterization of a mini-membrane protein, Ost4p: a subunit of yeast oligosaccharyl transferase.Biopolymers · 2012Article
- Chaperone-like properties of tobacco plastid thioredoxins f and m.Journal of experimental botany · 2012Article
- The conformational stability and biophysical properties of the eukaryotic thioredoxins of Pisum sativum are not family-conserved.PloS one · 2011Article
- Crystal structure of human thioredoxin revealing an unraveled helix and exposed S-nitrosation site.Protein science : a publication of the Protein Society · 2010Article
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4 authors at 2 institutions in 1 country.
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Abstract
We have examined the molecular weight and rotational correlation time of human thioredoxin by analytical ultracentrifugation and NMR spectroscopy, respectively. Two variants of human thioredoxin were studied, namely human thioredoxin identical in amino acid sequence to the one whose NMR structure we previously determined (C62A, C69A, C73A, M74T) and human thioredoxin (C62A, C69A, C73A, M74) containing the wild-type amino acid methionine at position 74. In both cases, the experimental data indicate that the predominant species is monomeric and we find no evidence for the existence of a well-defined dimeric form as was observed in the recently reported crystal structure (Weichsel et al., 1996) of human thioredoxin and the C73S mutant.
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