ArticleJournal of muscle research and cell motility1998
Effects of ADP and low ATP on the Ca(2+)-sensitive transient contraction upon photolysis of caged ATP in rat muscle fibres: a study on the Bremel-Weber type cooperation.
Article in Journal of muscle research and cell motility, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 2 citations in OpenAlex.
- Structural transients of contractile proteins upon sudden ATP liberation in skeletal muscle fibers.Biophysical journal · 2004Article
- Activating efficiency of Ca2+ and cross-bridges as measured by phosphate analog release.Biophysical journal · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Caged ATP was photolysed in rat psoas fibres under various conditions to examine whether ADP plays a special role in the 'Bremel-Weber type cooperation', viz. the Ca(2+)-like action of the rigor cross-bridges. Various concentrations of ATP (0.25-1.6 mM) were photoreleased in the presence of various concentrations of ADP (0-0.4 mM) at approximately 8 or 20 degrees C. The Ca2+ concentration was set at around 0.2 microM in order that the ATP-induced contraction was significant but short. Both lower [ATP] and higher [ADP] resulted in a slower detachment of the rigor cross-bridges and a larger contraction after the detachment. ADP did not seem to affect the relationship between the rate of detachment and the size of the Ca(2+)-sensitive component of the subsequent contraction. It is concluded that there is little evidence that the ADP-bound rigor cross-bridges are more potent than the nucleotide-free ones in the Bremel-Weber type cooperation that is seen in the ATP-induced transient contraction. The mechanism by which the ADP-specific, Ca(2+)-independent contraction occurs immediately after the release of ATP remains to be clarified.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.