ArticleJournal of muscle research and cell motility1998
Estimation of cross-bridge stiffness from maximum thermodynamic efficiency.
Article in Journal of muscle research and cell motility, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Theoretical efficiency limits and speed-efficiency trade-off in myosin motors.PLoS computational biology · 2023Article
- A Physiology-Guided Classification of Active-Stress and Active-Strain Approaches for Continuum-Mechanical Modeling of Skeletal Muscle Tissue.Frontiers in physiology · 2021Article
- Characterization of Electromechanical Delay Based on a Biophysical Multi-Scale Skeletal Muscle Model.Frontiers in physiology · 2019Article
- Do Actomyosin Single-Molecule Mechanics Data Predict Mechanics of Contracting Muscle?International journal of molecular sciences · 2018Review
- Dynamics of cross-bridge cycling, ATP hydrolysis, force generation, and deformation in cardiac muscle.Journal of molecular and cellular cardiology · 2016Article
- Role of catch bonds in actomyosin mechanics and cell mechanosensitivity.Physical review. E · 2016Article
- Adaptation of active tone in the mouse descending thoracic aorta under acute changes in loading.Biomechanics and modeling in mechanobiology · 2016Article
- Poorly understood aspects of striated muscle contraction.BioMed research international · 2015Review
- Design principles governing the motility of myosin V.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- From single molecule fluctuations to muscle contraction: a Brownian model of A.F. Huxley's hypotheses.PloS one · 2012Article
- Crossbridge and filament compliance in muscle: implications for tension generation and lever arm swing.Journal of muscle research and cell motility · 2010Review
- Actomyosin-ADP states, interhead cooperativity, and the force-velocity relation of skeletal muscle.Biophysical journal · 2010Article
- Single-molecule measurement of the stiffness of the rigor myosin head.Biophysical journal · 2008Article
- Stiffness and fraction of Myosin motors responsible for active force in permeabilized muscle fibers from rabbit psoas.Biophysical journal · 2007Article
- Mechanics of actomyosin bonds in different nucleotide states are tuned to muscle contraction.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Force generation in single conventional actomyosin complexes under high dynamic load.Biophysical journal · 2006Article
- Instabilities in the transient response of muscle.Biophysical journal · 2003Article
- The size and the speed of the working stroke of muscle myosin and its dependence on the force.The Journal of physiology · 2002Article
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1 author.
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Abstract
In muscle, work is performed by myosin cross-bridges during interactions with actin filaments. The amount of work performed during each interaction can be related to the mechanical properties of the cross-bridge; work is the integral of the force produced with respect to the distance that the cross-bridge moves the actin filament, and force is determined by the stiffness of the attached cross-bridge. In this paper, cross-bridge stiffness in frog sartorius muscle was estimated from thermodynamic efficiency (work/free energy change) using a two-state cross-bridge model, assuming constant stiffness over the working range and tight-coupling between cross-bridge cycles and ATP use. This model accurately predicts mechanical efficiency (work/enthalpy output). A critical review of the literature indicates that a realistic value for maximum thermodynamic efficiency of frog sartorius is 0.45 under conditions commonly used in experiments on isolated muscle. Cross-bridge stiffness was estimated for a range of power stroke amplitudes. For realistic amplitudes (10-15 nm), estimated cross-bridge stiffness was between 1 and 2.2 pN nm-1. These values are similar to those estimated from quick-release experiments, taking into account compliance arising from structures other than cross-bridges, but are substantially higher than those from isolated protein studies. The effects on stiffness estimates of relaxing the tight-coupling requirement and of incorporating more force-producing cross-bridge states are also considered.
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