ArticleThe Journal of cell biology1999
Matrix valency regulates integrin-mediated lymphoid adhesion via Syk kinase.
Article in The Journal of cell biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- Review
- Insights into the allosteric regulation of Syk association with receptor ITAM, a multi-state equilibrium.Physical chemistry chemical physics : PCCP · 2016Article
- Syk and pTyr'd: Signaling through the B cell antigen receptor.Biochimica et biophysica acta · 2009Review
- Role of the protein tyrosine kinase Syk in regulating cell-cell adhesion and motility in breast cancer cells.Molecular cancer research : MCR · 2009Article
- Tyr130 phosphorylation triggers Syk release from antigen receptor by long-distance conformational uncoupling.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Current advances and future challenges in Adenoviral vector biology and targeting.Current gene therapy · 2007Review
- Phosphorylation of focal adhesion kinase (FAK) on Ser732 is induced by rho-dependent kinase and is essential for proline-rich tyrosine kinase-2-mediated phosphorylation of FAK on Tyr407 in response to vascular endothelial growth factor.Molecular biology of the cell · 2006Article
- Synthetic multivalent ligands as probes of signal transduction.Angewandte Chemie (International ed. in English) · 2006Review
- Cell adhesion strengthening: contributions of adhesive area, integrin binding, and focal adhesion assembly.Molecular biology of the cell · 2005Article
- Hypermethylation of Syk gene in promoter region associated with oncogenesis and metastasis of gastric carcinoma.World journal of gastroenterology · 2004Article
- Beta-1 integrin-mediated adhesion may be initiated by multiple incomplete bonds, thus accounting for the functional importance of receptor clustering.Biophysical journal · 2004Article
- Visualizing lipid raft dynamics and early signaling events during antigen receptor-mediated B-lymphocyte activation.Molecular biology of the cell · 2003Article
- Integrin alphavbeta3, requirement for VEGFR2-mediated activation of SAPK2/p38 and for Hsp90-dependent phosphorylation of focal adhesion kinase in endothelial cells activated by VEGF.Cell stress & chaperones · 2003Article
- Plasmin-sensitive dibasic sequences in the third fibronectin-like domain of L1-cell adhesion molecule (CAM) facilitate homomultimerization and concomitant integrin recruitment.The Journal of cell biology · 2000Article
- Regulation of tissue injury responses by the exposure of matricryptic sites within extracellular matrix molecules.The American journal of pathology · 2000Review
- Regulation of adenovirus membrane penetration by the cytoplasmic tail of integrin beta5.Journal of virology · 2000Article
- Molecular signaling mechanisms of cell migration and invasion.Immunologic research · 2000Review
- Role of alpha(v) integrins in adenovirus cell entry and gene delivery.Microbiology and molecular biology reviews : MMBR · 1999Review
- Structure of adenovirus complexed with its internalization receptor, alphavbeta5 integrin.Journal of virology · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Lymphocytes accumulate within the extracellular matrix (ECM) of tumor, wound, or inflammatory tissues. These tissues are largely comprised of polymerized adhesion proteins such as fibrin and fibronectin or their fragments. Nonactivated lymphoid cells attach preferentially to polymerized ECM proteins yet are unable to attach to monomeric forms or fragments of these proteins without previous activation. This adhesion event depends on the appropriate spacing of integrin adhesion sites. Adhesion of nonactivated lymphoid cells to polymeric ECM components results in activation of the antigen receptor-associated Syk kinase that accumulates in adhesion-promoting podosomes. In fact, activation of Syk by antigen or agonists, as well as expression of an activated Syk mutant in lymphoid cells, facilitates their adhesion to monomeric ECM proteins or their fragments. These results reveal a cooperative interaction between signals emanating from integrins and antigen receptors that can serve to regulate stable lymphoid cell adhesion and retention within a remodeling ECM.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.