ArticleThe Journal of cell biology1999
The yeast dynamin-like protein, Mgm1p, functions on the mitochondrial outer membrane to mediate mitochondrial inheritance.
Article in The Journal of cell biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
57 citing papers in PubMed, 177 citations in OpenAlex.
- Pathways shaping the mitochondrial inner membrane.Open biology · 2021Review
- When the Balance Tips: Dysregulation of Mitochondrial Dynamics as a Culprit in Disease.International journal of molecular sciences · 2021Review
- Drug repositioning as a therapeutic strategy for neurodegenerations associated with OPA1 mutations.Human molecular genetics · 2021Article
- Mitochondrial Fission Protein 1: Emerging Roles in Organellar Form and Function in Health and Disease.Frontiers in endocrinology · 2021Review
- Structural analysis of a trimeric assembly of the mitochondrial dynamin-like GTPase Mgm1.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Bacterial dynamin-like protein DynA mediates lipid and content mixing.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- An evidence based hypothesis on the existence of two pathways of mitochondrial crista formation.eLife · 2016Article
- Phenotypic characterization and comparative transcriptomics of evolved Saccharomyces cerevisiae strains with improved tolerance to lignocellulosic derived inhibitors.Biotechnology for biofuels · 2016Article
- Structural basis of intramitochondrial phosphatidic acid transport mediated by Ups1-Mdm35 complex.EMBO reports · 2015Article
- Mitochondrial division and fusion in metabolism.Current opinion in cell biology · 2015Review
- Simultaneous impairment of mitochondrial fission and fusion reduces mitophagy and shortens replicative lifespan.Scientific reports · 2015Article
- Photoactivatable green fluorescent protein-based visualization and quantification of mitochondrial fusion and mitochondrial network complexity in living cells.Methods in enzymology · 2014Article
- Membrane-mediated aggregation of curvature-inducing nematogens and membrane tubulation.Biophysical journal · 2013Article
- Regulation of mitochondrial dynamics: convergences and divergences between yeast and vertebrates.Cellular and molecular life sciences : CMLS · 2013Review
- Over-expressing mitofusin-2 in healthy mature mammalian skeletal muscle does not alter mitochondrial bioenergetics.PloS one · 2013Article
- The power of yeast to model diseases of the powerhouse of the cell.Frontiers in bioscience (Landmark edition) · 2013Review
- Regulation of acid-base transporters by reactive oxygen species following mitochondrial fragmentation.American journal of physiology. Cell physiology · 2012Article
- The Role of the Transmembrane RING Finger Proteins in Cellular and Organelle Function.Membranes · 2011Article
- Dictyostelium dynamin B modulates cytoskeletal structures and membranous organelles.Cellular and molecular life sciences : CMLS · 2011Article
- The PARL family of mitochondrial rhomboid proteases.Seminars in cell & developmental biology · 2010Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The mdm17 mutation causes temperature-dependent defects in mitochondrial inheritance, mitochondrial morphology, and the maintenance of mitochondrial DNA in the yeast Saccharomyces cerevisiae. Defects in mitochondrial transmission to daughter buds and changes in mitochondrial morphology were apparent within 30 min after shifting cells to 37 degrees C, while loss of the mitochondrial genome occurred after 4-24 h at the elevated temperature. The mdm17 lesion mapped to MGM1, a gene encoding a dynamin-like GTPase previously implicated in mitochondrial genome maintenance, and the cloned MGM1 gene complements all of the mdm17 mutant phenotypes. Cells with an mgm1-null mutation displayed aberrant mitochondrial inheritance and morphology. A version of mgm1 mutated in a conserved residue in the putative GTP-binding site was unable to complement any of the mutant defects. It also caused aberrant mitochondrial distribution and morphology when expressed at high levels in cells that also contained a wild-type copy of the gene. Mgm1p was localized to the mitochondrial outer membrane and fractionated as a component of a high molecular weight complex. These results indicate that Mgm1p is a mitochondrial inheritance and morphology component that functions on the mitochondrial surface.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.