ArticleThe American journal of pathology1999
Specific and innervation-regulated expression of the intermediate filament protein nestin at neuromuscular and myotendinous junctions in skeletal muscle.
Article in The American journal of pathology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 94 citations in OpenAlex.
- Nestin and osteocrin mRNA increases in human semitendinosus myotendinous junction 7 days after a single bout of eccentric exercise.Histochemistry and cell biology · 2022Trial
- Muscle fibre denervation in ageing.Clinical science (London, England : 1979) · 2026Review
- Nestin expression in intact and hypertrophic myocardium of spontaneously hypertensive rats during aging.Journal of muscle research and cell motility · 2024Article
- Cellular and molecular alterations to muscles and neuromuscular synapses in a mouse model of MEGF10-related myopathy.Skeletal muscle · 2024Article
- Nestin is a New Partner in Endothelial Colony Forming Cell Angiogenic Potential.Stem cell reviews and reports · 2023Article
- Mechanical loading is required for initiation of extracellular matrix deposition at the developing murine myotendinous junction.Matrix biology : journal of the International Society for Matrix Biology · 2023Article
- Simple Methods for Permanent or Transient Denervation in Mouse Sciatic Nerve Injury Models.Bio-protocol · 2022Article
- Roles of vimentin in health and disease.Genes & development · 2022Review
- The proteomic profile of the human myotendinous junction.iScience · 2022Article
- In the human, true myocutaneous junctions of skeletal muscle fibers are limited to the face.Journal of anatomy · 2021Article
- Cytoskeletal Proteins in Myotendinous Junctions of Human Extraocular Muscles.Investigative ophthalmology & visual science · 2021Article
- The Biological Role of NestinFrontiers in cell and developmental biology · 2018Review
- Single-cell analysis reveals a nestinScience advances · 2016Article
- Special function of nestin(+) neurons in the medial septum-diagonal band of Broca in adult rats.Neural regeneration research · 2014Article
- Muscle injuries in athletes: enhancing recovery through scientific understanding and novel therapies.Sports health · 2013Article
- Nestin-expressing cells in the gut give rise to enteric neurons and glial cells.Neurogastroenterology and motility · 2013Article
- Nestin is not essential for development of the CNS but required for dispersion of acetylcholine receptor clusters at the area of neuromuscular junctions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Nestin as a regulator of Cdk5 in differentiating myoblasts.Molecular biology of the cell · 2011Article
- Nestin negatively regulates postsynaptic differentiation of the neuromuscular synapse.Nature neuroscience · 2011Article
- Expression of nestin, desmin and vimentin in intact and regenerating muscle spindles of rat hind limb skeletal muscles.Histochemistry and cell biology · 2009Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The intermediate filament proteins nestin, vimentin, and desmin show a specific temporal expression pattern during the development of myofibers from myogenic precursor cells. Nestin and vimentin are actively expressed during early developmental stages to be later down-regulated, vimentin completely and nestin to minimal levels, whereas desmin expression begins later and is maintained in mature myofibers, in which desmin participates in maintaining structural integrity. In this study we have analyzed the expression levels and distribution pattern of nestin in intact and denervated muscle in rat and in human. Nestin immunoreactivity was specifically and focally localized in the sarcoplasm underneath neuromuscular junctions (NMJs) and in the vicinity of the myotendinous junctions (MTJs), ie, in regions associated with acetylcholine receptors (AChRs). This association prompted us to analyze nestin in neurogenically and myogenically denervated muscle. Immunoblot analysis disclosed a marked overall increase of accumulated nestin protein. Similar to the extrajunctional redistribution of AChRs in denervated myofibers, nestin immunoreactivity extended widely beyond the NMJ region. Re-innervation caused complete reversion of these changes. Our study demonstrates that the expression levels and distribution pattern of nestin are regulated by innervation, ie, signal transduction into myofibers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.