ArticleThe American journal of pathology1999
Inhibition of angiogenesis induces chromaffin differentiation and apoptosis in neuroblastoma.
Article in The American journal of pathology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 63 citations in OpenAlex.
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- Uncovering a Key Role of ETS1 on Vascular Abnormality in Glioblastoma.Pathology oncology research : POR · 2021Article
- Cytotoxicity and genotoxicity of zingiberene on different neuron cell lines in vitro.Cytotechnology · 2015Article
- Quiescence and γH2AX in neuroblastoma are regulated by ouabain/Na,K-ATPase.British journal of cancer · 2012Article
- Regression of orthotopic neuroblastoma in mice by targeting the endothelial and tumor cell compartments.Journal of translational medicine · 2009Article
- Synergistic inhibition of human neuroblastoma-related angiogenesis by vinblastine and rapamycin.Oncogene · 2005Article
- Effect of antivascular endothelial growth factor treatment on the intratumoral uptake of CPT-11.British journal of cancer · 2003Article
- 2-Methoxyestradiol induces mitochondria dependent apoptotic signaling in pancreatic cancer cells.Oncogene · 2002Article
- Article
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5 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Inhibition of angiogenesis has been shown to reduce tumor growth, metastasis, and tumor microvascular density in experimental models. To these effects we would now like to add induction of differentiation, based on biological analysis of xenografted human neuroblastoma (SH-SY5Y, WAG rnu/rnu) treated with the angiogenesis inhibitor TNP-470. Treatment with TNP-470 (10 mg/kg s.c., n = 15) reduced the tumor growth by 66% and stereological vascular parameters (Lv, Vv, Sv) by 36-45%. The tumor cell apoptotic fraction increased more than threefold, resulting in a decrease in viable tumor cells by 33%. In contrast, the mean vascular diameter (29 microm) and the mean tumor cell proliferative index (49%) were unaffected. TNP-470-treated tumors exhibited striking chromaffin differentiation of neuroblastoma cells, observed as increased expression of insulin-like growth factor II gene (+88%), tyrosine hydroxylase (+96%), chromogranin A, and cellular processes. Statistical analysis revealed an inverse correlation between differentiation and angiogenesis. It is suggested that by inhibiting angiogenesis, TNP-470 induces metabolic stress, resulting in chromaffin differentiation and apoptosis in neuroblastoma. Such agonal differentiation may be the link between angiostatic therapy and tumor cell apoptosis.
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