Trial reportBritish journal of sports medicine1999
Changes in haematological parameters and iron metabolism associated with a 1600 kilometre ultramarathon.
Trial report in British journal of sports medicine, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Factors Confounding the Athlete Biological Passport: A Systematic Narrative Review.Sports medicine - open · 2021Pooled it
- Musculoskeletal (Mal)adaptations in Response to a > 30 000-km Running Challenge.Journal of cachexia, sarcopenia and muscle · 2026Article
- Article
- Accelerated Red Blood Cell Turnover Following Extreme Mountain Ultramarathon?Medicine and science in sports and exercise · 2025Article
- Running on the edge: hematological responses to a non-stop ultramarathon with a focus on nitric oxide-mediated red blood cell deformability.Frontiers in physiology · 2025Article
- Epidemiological, biological and clinical update on exercise-induced hemolysis.Annals of translational medicine · 2019Review
- Physiology and Pathophysiology in Ultra-Marathon Running.Frontiers in physiology · 2018Review
- Stability in post-seasonal hematological profiles in response to high-competitive match-play loads within elite top-level European soccer players: implications from a pilot study.Open access journal of sports medicine · 2018Article
- Hematological and Biochemical Parameters in Elite Soccer Players During A Competitive Half Season.Journal of medical biochemistry · 2015Article
- Variation of red blood cell distribution width and mean platelet volume after moderate endurance exercise.Advances in hematology · 2014Article
- Muscular damage and intravascular haemolysis during an 18 hour subterranean exploration in a cave of 700 m depth.British journal of sports medicine · 2006Article
- The acute phase response and exercise: court and field sports.British journal of sports medicine · 2001Article
- The immune system in sport: getting the balance right.British journal of sports medicine · 2000Review
- Exercise for cancer patients: a new challenge in sports medicine.British journal of sports medicine · 2000Article
- The biochemistry of runners in a 1600 km ultramarathon.British journal of sports medicine · 1999Article
- Comparative evaluation of C-reactive protein and complete blood count in chronic periodontitis patients following Phase I therapy: A serological and hematological study.Journal of Indian Society of PeriodontologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate haematological variations and iron related changes in the serum of participants in a 1600 kilometre ultramarathon run.
participantsSeven male and two female participants in a 1600 km foot race.
methodsBlood samples were obtained from the participants before, after four and 11 days of running, and at the end of the event. Samples were analysed by standard methods for haemoglobin, packed cell volume, total red cell count, mean red cell volume, mean red cell haemoglobin, total white cell count and differential, platelets, reticulocytes, iron, ferritin, total iron binding capacity, percentage transferrin saturation, haptoglobin, and bilirubin and corrected for changes in plasma volume.
resultsThe following variables decreased during the event (p < 0.05): haemoglobin, packed cell volume, mean red cell volume, percentage lymphocytes, percentage monocytes, serum iron, total iron binding capacity, and percentage transferrin saturation. Increases (p < 0.05) were found in plasma volume, total red cell count (day 4 only), total white cell count, percentage and absolute numbers of neutrophils and reticulocytes, absolute numbers of lymphocytes and monocytes (day 4 only), absolute numbers of eosinophils (day 11 and race end), absolute numbers of basophils (race end only), platelets, ferritin, haptoglobin, and bilirubin (day 4 only).
conclusionUltramarathon running is associated with a wide range of changes in haematological parameters, many of which are related to the normal acute phase response to injury. These should not be confused with indicators of disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.