ArticleGut1999
Predicting bone loss following orthotopic liver transplantation.
Article in Gut, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 58 citations in OpenAlex.
- Effects of alendronate on bone mineral density and bone metabolic markers in patients with liver transplantation.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2006Trial
- Association between osteoporosis and waitlist mortality in liver transplant candidates.Scientific reports · 2026Article
- Hepatic osteodystrophy.Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases · 2014Review
- Treatment of bone loss in patients with chronic liver disease awaiting liver transplantation.Transplantation research · 2012Article
- Changes in vitamin D binding protein and vitamin D concentrations associated with liver transplantation.Liver international : official journal of the International Association for the Study of the Liver · 2012Article
- Vitamin D status in gastrointestinal and liver disease.Current opinion in gastroenterology · 2008Review
- Bone mineral density loss in patients with cirrhosis.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHepatic osteodystrophy occurs in the majority of patients with advanced chronic liver disease with the abnormalities in bone metabolism accelerating following orthotopic liver transplantation (OLT).
aimsTo examine changes in bone mineral density (BMD) following OLT and to investigate factors that lead to bone loss.
methodsTwelve patients had BMD (at both the lumbar spine (LS) and femoral neck (FN)) and biochemical markers measured preoperatively and for 24 months following OLT.
resultsBMD was low in 75% of patients prior to OLT and decreased significantly from baseline at the LS at three months and the FN at six months. BMD began to increase thereafter at both sites, approaching baseline values at the LS by 12 months. Bone formation markers, osteocalcin and procollagen type I carboxy propeptide, decreased immediately post-OLT, with a concomitant increase seen in the resorption markers pyridinoline and deoxypyridinoline. This resulted in a negative uncoupling index early post-OLT, that rebounded to positive values after six months. There was a significant correlation between the change in the uncoupling index between six and three months which preceded the increase in BMD at 12 months. The decrease in BMD recorded early post-OLT correlated with vitamin D levels at three months.
conclusionsResults suggest that increased resorption and inadequate formation are the major contributors to additional bone loss following OLT. Non-invasive biochemical markers precede later changes in BMD in this patient group following OLT and may have a role in investigating and planning intervention strategies to prevent bone loss in future studies.
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