Evidence map›Paper›PMID 10024605›Full record

ArticleInfection and immunity1999

Correlation of temperature and toxicity in murine studies of staphylococcal enterotoxins and toxic shock syndrome toxin 1.

B G Stiles, Y G Campbell, R M Castle, S A Grove

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 65 citations in OpenAlex.

  1. Article
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  5. Combination with a FtsZ inhibitor potentiates the in vivo efficacy of oxacillin against methicillin-resistantMedicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2022
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  20. Identification of markers for imminent death in mice used in longevity and aging research.Journal of the American Association for Laboratory Animal Science : JAALAS · 2010
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

B G StilesDepartment of Immunology and Molecular Biology, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702-5011, USA.dr.bradleystiles@detrick.army.mil
Y G Campbell
R M Castle
S A Grove
United States Army Medical Research Institute of Infectious Diseases · USShippensburg University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study describes a quick (<12 h) assay for detecting temperature decreases in BALB/c and C57BL/6 mice injected intraperitoneally (i.p. ) with staphylococcal enterotoxin A (SEA), SEB, or SEC3 or toxic shock syndrome toxin 1 and a potentiating dose of lipopolysaccharide (LPS). Toxin-specific antisera effectively neutralized the temperature fluctuations in this model. Orally administered SEA or SEB (50 microg/animal), with or without LPS, did not have an effect on temperature or lethality. Versus wild-type mice, transgenic knockout mice lacking the p55 receptor for tumor necrosis factor (TNF) or gamma interferon were protected against an i.p. challenge of SEA plus LPS. The p75 receptor for TNF and intercellular adhesion molecule 1 have a negligible role in this toxic shock model.

Indexed as

Bacterial ToxinsSuperantigensAnimalsBody TemperatureCytokinesEnterotoxinsLipopolysaccharidesMaleMiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutStaphylococcus aureusBacterial ToxinsCytokinesenterotoxin A, Staphylococcalenterotoxin B, staphylococcalenterotoxin C, staphylococcalenterotoxin F, StaphylococcalEnterotoxinsLipopolysaccharidesSuperantigens

Identifiers

PMID10024605
PMCPMC96491
OpenAlexW2143889741

What OpenQuestion holds

Texttitle and abstract
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.