ArticleInfection and immunity1999
Expression of the plague plasminogen activator in Yersinia pseudotuberculosis and Escherichia coli.
Article in Infection and immunity, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 49 citations in OpenAlex.
- Article
- Review
- Article
- Genomic Insights into a New Citrobacter koseri Strain Revealed Gene Exchanges with the Virulence-Associated Yersinia pestis pPCP1 Plasmid.Frontiers in microbiology · 2016Article
- Evaluation of the Role of the opgGH Operon in Yersinia pseudotuberculosis and Its Deletion during the Emergence of Yersinia pestis.Infection and immunity · 2015Article
- Early emergence of Yersinia pestis as a severe respiratory pathogen.Nature communications · 2015Article
- A multi-omic systems approach to elucidating Yersinia virulence mechanisms.Molecular bioSystems · 2013Article
- Fast and simple detection of Yersinia pestis applicable to field investigation of plague foci.PloS one · 2013Article
- Cluster analysis of host cytokine responses to biodefense pathogens in a whole blood ex vivo exposure model (WEEM).BMC microbiology · 2012Article
- Delineation and analysis of chromosomal regions specifying Yersinia pestis.Infection and immunity · 2010Article
- Deletion of Braun lipoprotein gene (lpp) and curing of plasmid pPCP1 dramatically alter the virulence of Yersinia pestis CO92 in a mouse model of pneumonic plague.Microbiology (Reading, England) · 2009Article
- The single substitution I259T, conserved in the plasminogen activator Pla of pandemic Yersinia pestis branches, enhances fibrinolytic activity.Journal of bacteriology · 2009Article
- Article
- Human dendritic cell-specific intercellular adhesion molecule-grabbing nonintegrin (CD209) is a receptor for Yersinia pestis that promotes phagocytosis by dendritic cells.Infection and immunity · 2008Article
- Direct transcriptional control of the plasminogen activator gene of Yersinia pestis by the cyclic AMP receptor protein.Journal of bacteriology · 2007Article
- A surface-focused biotinylation procedure identifies the Yersinia pestis catalase KatY as a membrane-associated but non-surface-located protein.Applied and environmental microbiology · 2007Article
- Current trends in plague research: from genomics to virulence.Clinical medicine & research · 2006Review
- Influence of Na(+), dicarboxylic amino acids, and pH in modulating the low-calcium response of Yersinia pestis.Infection and immunity · 2005Article
- Insights into the evolution of Yersinia pestis through whole-genome comparison with Yersinia pseudotuberculosis.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- The yersiniae--a model genus to study the rapid evolution of bacterial pathogens.Nature reviews. Microbiology · 2003Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Enteropathogenic yersiniae (Yersinia pseudotuberculosis and Yersinia enterocolitica) typically cause chronic disease as opposed to the closely related Yersinia pestis, the causative agent of bubonic plague. It is established that this difference reflects, in part, carriage by Y. pestis of a unique 9.6-kb pesticin or Pst plasmid (pPCP) encoding plasminogen activator (Pla) rather than distinctions between shared approximately 70-kb low-calcium-response, or Lcr, plasmids (pCD in Y. pestis and pYV in enteropathogenic yersiniae) encoding cytotoxic Yops and anti-inflammatory V antigen. Pla is known to exist as a combination of 32.6-kDa (alpha-Pla) and slightly smaller (beta-Pla) outer membrane proteins, of which at least one promotes bacterial dissemination in vivo and degradation of Yops in vitro. We show here that only alpha-Pla accumulates in Escherichia coli LE392/pPCP1 cultivated in enriched medium and that either autolysis or extraction of this isolate with 1.0 M NaCl results in release of soluble alpha and beta forms possessing biological activity. This process also converted cell-bound alpha-Pla to beta-Pla and smaller forms in Y. pestis KIM/pPCP1 and Y. pseudotuberculosis PB1/+/pPCP1 but did not promote solubilization. Pla-mediated posttranslational hydrolysis of pulse-labeled Yops in Y. pseudotuberculosis PB1/+/pPCP1 occurred more slowly than that in Y. pestis but was otherwise similar except for accumulation of stable degradation products of YadA, a pYV-mediated fibrillar adhesin not encoded in frame by pCD. Carriage of pPCP by Y. pseudotuberculosis did not significantly influence virulence in mice.
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