ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Neural changes after operant conditioning of the aerial respiratory behavior in Lymnaea stagnalis.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 112 citations in OpenAlex.
- Distinct Proteomic Brain States Underlying Long-Term Memory Formation in Aversive Operant Conditioning.Journal of proteome research · 2025Article
- Investigating the interactions between multiple memory stores in the pond snail Lymnaea stagnalis.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Article
- Remember the poke: microRNAs are required for long-term memory formation following operant conditioning in Lymnaea.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2023Article
- A flavonoid, quercetin, is capable of enhancing long-term memory formation if encountered at different times in the learning, memory formation, and memory recall continuum.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2022Article
- What can we teach Lymnaea and what can Lymnaea teach us?Biological reviews of the Cambridge Philosophical Society · 2021Review
- Learning and Its Neural Correlates in a Virtual Environment for Honeybees.Frontiers in behavioral neuroscience · 2018Article
- Training Lymnaea in the presence of a predator scent results in a long-lasting ability to form enhanced long-term memory.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2016Article
- Inverse Relationship between Basal Pacemaker Neuron Activity and Aversive Long-Term Memory Formation inFrontiers in cellular neuroscience · 2016Article
- Electrophysiological characteristics of feeding-related neurons after taste avoidance Pavlovian conditioning in Lymnaea stagnalis.Biophysics (Nagoya-shi, Japan) · 2014Review
- Phospholipase A2 - nexus of aging, oxidative stress, neuronal excitability, and functional decline of the aging nervous system? Insights from a snail model system of neuronal aging and age-associated memory impairment.Frontiers in genetics · 2014Review
- Combining stressors that individually impede long-term memory blocks all memory processes.PloS one · 2013Article
- A sodium leak current regulates pacemaker activity of adult central pattern generator neurons in Lymnaea stagnalis.PloS one · 2011Article
- Neural mechanisms of operant conditioning and learning-induced behavioral plasticity in Aplysia.Cellular and molecular life sciences : CMLS · 2011Review
- The participation of NMDA receptors, PKC, and MAPK in the formation of memory following operant conditioning in Lymnaea.Molecular brain · 2010Article
- Electrophysiological and behavioral evidence demonstrating that predator detection alters adaptive behaviors in the snail Lymnaea.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Behavioral and in vitro correlates of compulsive-like food seeking induced by operant conditioning in Aplysia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Operant conditioning of gill withdrawal in Aplysia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Extinction requires new RNA and protein synthesis and the soma of the cell right pedal dorsal 1 in Lymnaea stagnalis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Reconsolidation of a long-term memory in Lymnaea requires new protein and RNA synthesis and the soma of right pedal dorsal 1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Voltage-dependent switching of sensorimotor integration by a lobster central pattern generator.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we demonstrate neural changes that occurred during operant conditioning of the aerial respiratory behavior of Lymnaea stagnalis. Aerial respiration in Lymnaea occurs at the water interface and is achieved by opening and closing movements of its respiratory orifice, the pneumostome. This behavior is controlled by a central pattern generator (CPG), the neurons of which, as well as the motoneurons innervating the pneumostome, have previously been identified and their synaptic connections well characterized. The respiratory behavior was operantly conditioned by applying a mechanical stimulus to the open pneumostome whenever the animal attempted to breathe. This negative reinforcement to the open pneumostome resulted in its immediate closure and a significant reduction in the overall respiratory activity. Electrophysiological recordings from the isolated CNSs after operant conditioning showed that the spontaneous patterned respiratory activity of the CPG neurons was significantly reduced. This included reduced spontaneous activity of the CPG interneuron involved in pneumostome opening (input 3 interneuron) and a reduced frequency of spontaneous tonic activity of the CPG interneuron [right pedal dorsal 1 (RPeD1)]. The ability to trigger the patterned respiratory activity by electrical stimulation of RPeD1 was also significantly reduced after operant conditioning. This study therefore demonstrates significant changes within a CPG that are associated with changes in a rhythmic homeostatic behavior after operant conditioning.
Indexed as
Identifiers
10024367PMC6782184W1583880599What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.