ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Activation of human D3 dopamine receptor inhibits P/Q-type calcium channels and secretory activity in AtT-20 cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
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- Abnormalities of Dopamine DJournal of central nervous system disease · 2017Review
- Striatal dopamine neurotransmission: regulation of release and uptake.Basal ganglia · 2016Article
- An amino acid residue in the second extracellular loop determines the agonist-dependent tolerance property of the human D3 dopamine receptor.ACS chemical neuroscience · 2013Article
- Interaction of D₃ preferring agonist (-)-N⁶-(2-(4-(biphenyl-4-yl)piperazin-1-yl)ethyl)-N⁶-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine (D-264) with cloned human D₂L, D₂S, and D₃ receptors: potent stimulation of mitogen-activated protein kinases and G protein-coupled inward rectifier potassium channels.Naunyn-Schmiedeberg's archives of pharmacology · 2013Article
- Molecular characterization of individual D3 dopamine receptor-expressing cells isolated from multiple brain regions of a novel mouse model.Brain structure & function · 2012Article
- Identification and characterization of a novel class of atypical dopamine receptor agonists.Pharmaceutical research · 2012Article
- Regulation of striatal dopamine release by presynaptic auto- and heteroreceptors.Basal ganglia · 2012Article
- Dopamine receptor signaling and current and future antipsychotic drugs.Handbook of experimental pharmacology · 2012Review
- Third generation antipsychotic drugs: partial agonism or receptor functional selectivity?Current pharmaceutical design · 2010Review
- Pharmacological characterisation of native somatostatin receptors in AtT-20 mouse tumour corticotrophs.British journal of pharmacology · 2003Article
- Dopamine D3 receptor antagonism inhibits cocaine-seeking and cocaine-enhanced brain reward in rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Amphetamine blocks long-term synaptic depression in the ventral tegmental area.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Dominant-negative mutants identify a role for GIRK channels in D3 dopamine receptor-mediated regulation of spontaneous secretory activity.The Journal of general physiology · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The D3 dopamine receptor is postulated to play an important role in the regulation of neurotransmitter secretion at both pre- and postsynaptic terminals. However, this hypothesis and the underlying mechanisms remain untested because of the lack of D3-selective ligands, paucity of appropriate model secretory systems, and the weak and inconsistent coupling of D3 receptors to classical signal transduction pathways. The absence of ligands that selectively discriminate between D3 and D2 receptors in vivo precludes the study of D3 receptor function in the brain and necessitates the use of heterologous expression systems. In this report we demonstrate that activation of the human D3 dopamine receptor expressed in the AtT-20 neuroendocrine cell line causes robust inhibition of P/Q-type calcium channels via pertussis toxin-sensitive G-proteins. In addition, using the vesicle trafficking dye FM1-43, we show that D3 receptor activation significantly inhibits spontaneous secretory activity in these cells. Our results not only support the hypothesis that the D3 receptor can regulate secretory activity but also provide insight into the underlying signaling mechanisms. We propose a functional model in which the D3 receptor tightly regulates neurotransmitter release at a synapse by only allowing the propagation of spikes above a certain frequency or burst-duration threshold.
Indexed as
Identifiers
10024356PMC6782181W2103299253What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.