ArticleScience (New York, N.Y.)1999
Regulation of neurotrophin-3 expression by epithelial-mesenchymal interactions: the role of Wnt factors.
Article in Science (New York, N.Y.), 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 66 citations in OpenAlex.
- Spatiotemporal Molecular Architecture of Lineage Allocation and Cellular Organization in Tooth Morphogenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Influencers in the Somatosensory System: Extrinsic Control of Sensory Neuron Phenotypes.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2023Review
- Transcriptome Profiling of the Hippocampal Seizure Network Implicates a Role for Wnt Signaling during Epileptogenesis in a Mouse Model of Temporal Lobe Epilepsy.International journal of molecular sciences · 2022Article
- Nobel somatosensations and pain.Pflugers Archiv : European journal of physiology · 2022Review
- Regulating muscle spindle and Golgi tendon organ proprioceptor phenotypes.Current opinion in physiology · 2021Article
- Molecular and Cellular Mechanisms Associated with Effects of Molecular Hydrogen in Cardiovascular and Central Nervous Systems.Antioxidants (Basel, Switzerland) · 2020Review
- TNFα and IL-1β modify the miRNA cargo of astrocyte shed extracellular vesicles to regulate neurotrophic signaling in neurons.Cell death & disease · 2018Article
- Molecular control of the neural crest and peripheral nervous system development.Current topics in developmental biology · 2015Review
- Loss of neurotrophin-3 from smooth muscle disrupts vagal gastrointestinal afferent signaling and satiation.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- Neurotrophin and Wnt signaling cooperatively regulate dendritic spine formation.Molecular and cellular neurosciences · 2013Article
- SAD kinases sculpt axonal arbors of sensory neurons through long- and short-term responses to neurotrophin signals.Neuron · 2013Article
- Expression of brain-derived neurotrophic factor is regulated by the Wnt signaling pathway.Neuroreport · 2012Article
- Selective regulation of nerve growth factor expression in developing cutaneous tissue by early sensory innervation.Neural development · 2011Article
- Smooth-muscle-specific expression of neurotrophin-3 in mouse embryonic and neonatal gastrointestinal tract.Cell and tissue research · 2010Article
- Louis Reichardt: the long climb to science's summits.The Journal of cell biology · 2009Article
- Nerve growth factor and receptor expression in rheumatoid arthritis and spondyloarthritis.Arthritis research & therapy · 2009Article
- Factors regulating vagal sensory development: potential role in obesities of developmental origin.Physiology & behavior · 2008Article
- Characterization of Wnt signaling during photoreceptor degeneration.Investigative ophthalmology & visual science · 2007Article
- Neurotrophin-regulated signalling pathways.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2006Review
- Expressing TrkC from the TrkA locus causes a subset of dorsal root ganglia neurons to switch fate.Nature neuroscience · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
Abstract
Neurotrophins regulate survival, axonal growth, and target innervation of sensory and other neurons. Neurotrophin-3 (NT-3) is expressed specifically in cells adjacent to extending axons of dorsal root ganglia neurons, and its absence results in loss of most of these neurons before their axons reach their targets. However, axons are not required for NT-3 expression in limbs; instead, local signals from ectoderm induce NT-3 expression in adjacent mesenchyme. Wnt factors expressed in limb ectoderm induce NT-3 in the underlying mesenchyme. Thus, epithelial-mesenchymal interactions mediated by Wnt factors control NT-3 expression and may regulate axonal growth and guidance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.