ArticleAnnals of surgery1999
Route and type of nutrition influence mucosal immunity to bacterial pneumonia.
Article in Annals of surgery, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 120 citations in OpenAlex.
- A qualitative systematic review of family caregivers' experiences of artificial nutrition and hydration at home: A meta-ethnography.International journal of language & communication disorders · 2022Pooled it
- Enteral versus parenteral nutrition and enteral versus a combination of enteral and parenteral nutrition for adults in the intensive care unit.The Cochrane database of systematic reviews · 2018Pooled it
- Gastrointestinal immune and microbiome changes during parenteral nutrition.American journal of physiology. Gastrointestinal and liver physiology · 2017Review
- Bombesin Preserves Goblet Cell Resistin-Like Molecule β During Parenteral Nutrition but Not Other Goblet Cell Products.JPEN. Journal of parenteral and enteral nutrition · 2016Article
- Innate Mucosal Immune System Response of BALB/c vs C57BL/6 Mice to Injury in the Setting of Enteral and Parenteral Feeding.JPEN. Journal of parenteral and enteral nutrition · 2016Article
- The gastrointestinal immune system: Implications for the surgical patient.Current problems in surgery · 2016Review
- Gut Lymphocyte Phenotype Changes After Parenteral Nutrition and Neuropeptide Administration.Annals of surgery · 2015Article
- Review
- Bombesin improves adaptive immunity of the salivary gland during parenteral nutrition.JPEN. Journal of parenteral and enteral nutrition · 2015Article
- Animal models of gastrointestinal and liver diseases. Animal models of infant short bowel syndrome: translational relevance and challenges.American journal of physiology. Gastrointestinal and liver physiology · 2014Review
- Article
- The enteric nervous system neuropeptide, bombesin, reverses innate immune impairments during parenteral nutrition.Annals of surgery · 2014Article
- Small intestine mucosal immune system response to injury and the impact of parenteral nutrition.Surgery · 2012Article
- Nutrition and gut immunity.The Surgical clinics of North America · 2011Review
- Injury induces localized airway increases in pro-inflammatory cytokines in humans and mice.Surgical infections · 2011Article
- Proinflammatory cytokine surge after injury stimulates an airway immunoglobulin a increase.The Journal of trauma · 2010Article
- Decreased phospho-Akt signaling in a mouse model of total parenteral nutrition: a potential mechanism for the development of intestinal mucosal atrophy.American journal of physiology. Gastrointestinal and liver physiology · 2010Article
- Parenteral nutrition maintains pulmonary IgA antibody transport capacity, but not active transport, following injury.American journal of surgery · 2009Article
- Food fight! Parenteral nutrition, enteral stimulation and gut-derived mucosal immunity.Langenbeck's archives of surgery · 2009Review
- Parenteral nutrition induces organ specific alterations in polymeric immunoglobulin receptor levels.The Journal of surgical research · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo develop a model of established respiratory immunity against Pseudomonas aeruginosa pneumonia and to investigate the effects of route and type of nutrition on this immunity. SUMMARY BACKGROUND DATA: Diet influences the ability of gut-associated lymphoid tissue (GALT) to maintain mucosal immunity. Complex enteral diets and chow maintain normal GALT populations against established IgA-mediated antiviral respiratory immunity. Both intravenous and intragastric total parenteral nutrition (TPN) produce GALT atrophy, but only intragastric TPN preserves established antiviral immunity. The authors hypothesized that both GALT-depleting diets (intragastric and intravenous TPN) would impair immunity against bacterial pneumonia.
methodsP. aeruginosa was administered intratracheally to determine the mortality rate at increasing doses, and liposomes containing P. aeruginosa antigens were used to generate effective respiratory immunization. In the final experiment, mice received liposomes containing P. aeruginosa antigens to establish immunity and then were randomized to chow, complex enteral diets, intragastric TPN, or intravenous TPN. After 5 days of diet, mice received live intratracheal P. aeruginosa, and the death rate was recorded at 24 and 48 hours.
resultsThe LD50 and LD100 were 9 x 10(7) and 12 x 10(7), respectively. Immunization reduced the mortality rate from 66% to 12%. This immunization was maintained in mice fed chow or a complex enteral diet and was lost in animals receiving intravenous TPN. Intragastric TPN partially preserved this respiratory immunity.
conclusionsProtection against bacterial pneumonia can be induced by prior antigenic immunization. This protection is lost with intravenous TPN, partially preserved with a chemically defined enteral diet, and completely preserved with chow or complex enteral diets. Both route and type of nutrition influence antibacterial respiratory tract immunity.
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