ArticleAnnals of surgery1999
HLA-DR expression and soluble HLA-DR levels in septic patients after trauma.
Article in Annals of surgery, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
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The trial behind it
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Who cites it
62 citing papers in PubMed, 189 citations in OpenAlex.
- Innate immunity recovers earlier than acquired immunity during severe postoperative immunosuppression.International journal of medical sciences · 2018Trial
- Intensive versus conventional insulin therapy in nondiabetic patients receiving parenteral nutrition after D2 gastrectomy for gastric cancer: a randomized controlled trial.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2011Trial
- HLA-DR as a marker for increased risk for systemic inflammation and septic complications after cardiac surgery.Intensive care medicine · 2003Trial
- Is low monocyte HLA-DR expression helpful to predict outcome in severe sepsis?Intensive care medicine · 2003Trial
- Interferon-gamma administration after abdominal surgery rescues antigen-specific helper T cell immune reactivity.Clinical and experimental immunology · 2001Trial
- Metabolic adaptations rewire CD4Nature immunology · 2026Article
- Sympathetic regulation of the host immune response to bacterial sepsis.Clinical science (London, England : 1979) · 2025Review
- Prognostic Value of Peripheral Blood nCD64 Index, mHLA-DR, and CD14Journal of inflammation research · 2025Article
- Spectral cytometry of rheumatoid arthritis patients implicates myeloid dendritic cells and granular HLA-DR+CD15+CD16+ cells in pro-inflammatory antigen presentation.Frontiers in immunology · 2025Article
- Multi-omic analysis of PBMCs in sepsis reveals widespread cytotoxic dysfunction and an increased population ofFrontiers in immunology · 2025Article
- Monocytic HLA-DR Expression in Immune Responses of Acute Pancreatitis and COVID-19.International journal of molecular sciences · 2023Review
- The emerging roles and therapeutic potential of B cells in sepsis.Frontiers in pharmacology · 2022Review
- Measures of Systemic Innate Immune Function Predict the Risk of Nosocomial Infection in Pediatric Burn Patients.Journal of burn care & research : official publication of the American Burn Association · 2021Observational
- T-cell activation profiles distinguish hemophagocytic lymphohistiocytosis and early sepsis.Blood · 2021Article
- Electroacupuncture Attenuates Surgical Stress-Induced Reduction of T Lymphocytes through Modulation of Peripheral Opioid System.Chinese journal of integrative medicine · 2021Article
- Infection of Monocytes From Tuberculosis Patients With Two Virulent Clinical Isolates ofFrontiers in cellular and infection microbiology · 2020Article
- Flow Cytometric Analysis of Hematopoietic Populations in Rat Bone Marrow. Impact of Trauma and Hemorrhagic Shock.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2019Article
- The CD14Frontiers in immunology · 2019Review
- Evidence for Persistent Immune Suppression in Patients Who Develop Chronic Critical Illness After Sepsis.Shock (Augusta, Ga.) · 2018Observational
- Soluble HLA-I and HLA-II Molecules Are Potential Prognostic Markers of Progression of Systemic and Local Inflammation in Patients with COPD.Disease markers · 2018Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine if cellular and soluble HLA-DR molecules may be relevant in severely injured patients for the development of gram-positive or gram-negative sepsis. SUMMARY BACKGROUND DATA: HLA-DR molecules play a central role in the specific immune response to infection. The reduced HLA-DR expression on monocytes is considered to correlate with infectious complications and the development of sepsis. Data on the role of HLA-DR expression on T cells and soluble HLA-DR molecules are rare.
methodsHLA-DR expression on monocytes and T cells was measured by flow cytometry. Plasma levels of soluble HLA-DR were studied by enzyme-linked immunosorbent assay.
resultsHLA-DR expression on circulating T cells, calculated as mean fluorescence intensity in channels, was reduced at day 1 after admission in 20 patients with subsequent severe sepsis compared with 46 patients without sepsis. The septic patients immediately after trauma had significantly lower soluble HLA-DR plasma levels than the nonseptic patients. At day 2 after admission, HLA-DR expression on monocytes was significantly lower in the severe sepsis group than in the patients without sepsis, and lasted until day 14 after injury.
conclusionsIn severely injured patients, decreased levels of cellular and soluble HLA-DR appear as early indicators of an immune deviation associated with the development of severe sepsis. Moreover, immune alterations of different cell types may promote distinct kinds of septicemia.
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