ArticleAnnals of surgery1999
Activation of alveolar macrophages in lung injury associated with experimental acute pancreatitis is mediated by the liver.
Article in Annals of surgery, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 110 citations in OpenAlex.
- P2X7 receptor antagonists modulate experimental autoimmune neuritis via regulation of NLRP3 inflammasome activation and Th17 and Th1 cell differentiation.Journal of neuroinflammation · 2024Article
- Emodin attenuates severe acute pancreatitis-associated acute lung injury by suppressing pancreatic exosome-mediated alveolar macrophage activation.Acta pharmaceutica Sinica. B · 2022Article
- Tumor markers are associated with rapidly progressive interstitial lung disease in adult-dermatomyositis.Clinical rheumatology · 2022Article
- LincRNA-EPS alleviates severe acute pancreatitis by suppressing HMGB1-triggered inflammation in pancreatic macrophages.Immunology · 2021Article
- Gender Differences in Low-Molecular-Mass-Induced Acute Lung Inflammation in Mice.International journal of molecular sciences · 2021Article
- The Clinical Characteristics of Acute Pancreatitis in Gerontal Patients: A Retrospective Study.Clinical interventions in aging · 2020Article
- Surfactant Protein D Dampens Lung Injury by Suppressing NLRP3 Inflammasome Activation and NF-κB Signaling in Acute Pancreatitis.Shock (Augusta, Ga.) · 2019Article
- Role of obesity in the release of extracellular nucleosomes in acute pancreatitis: a clinical and experimental study.International journal of obesity (2005) · 2019Article
- Autophagy, Inflammation, and Immune Dysfunction in the Pathogenesis of Pancreatitis.Gastroenterology · 2017Review
- HMGB1 and Histones Play a Significant Role in Inducing Systemic Inflammation and Multiple Organ Dysfunctions in Severe Acute Pancreatitis.International journal of inflammation · 2017Review
- Involvement of the PI3K/Akt/NF-BioMed research international · 2017Article
- Mannose-coated gadolinium liposomes for improved magnetic resonance imaging in acute pancreatitis.International journal of nanomedicine · 2017Article
- Reverse-migrated neutrophils regulated by JAM-C are involved in acute pancreatitis-associated lung injury.Scientific reports · 2016Article
- New Roles for Corticosteroid Binding Globulin and Opposite Expression Profiles in Lung and Liver.PloS one · 2016Article
- Minocycline inhibits peritoneal macrophages but activates alveolar macrophages in acute pancreatitis.Journal of physiology and biochemistry · 2015Article
- Duration of injury correlates with necrosis in caerulein-induced experimental acute pancreatitis: implications for pathophysiology.International journal of experimental pathology · 2014Article
- Treatment with ginkgo biloba extract protects rats against acute pancreatitis-associated lung injury by modulating alveolar macrophage.Przeglad gastroenterologiczny · 2014Article
- Clodronate-containing liposomes attenuate lung injury in rats with severe acute pancreatitis.Journal of Zhejiang University. Science. B · 2010Article
- Role of macrophages in the progression of acute pancreatitis.World journal of gastrointestinal pharmacology and therapeutics · 2010Article
- Essential role of monocytes and macrophages in the progression of acute pancreatitis.World journal of gastroenterology · 2010Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate (1) whether alveolar macrophages are activated as a consequence of acute pancreatitis (AP), (2) the implication of inflammatory factors released by these macrophages in the process of neutrophil migration into the lungs observed in lung injury induced by AP, and (3) the role of the liver in the activation of alveolar macrophages. SUMMARY BACKGROUND DATA: Acute lung injury is the extrapancreatic complication most frequently associated with death and complications in severe AP. Neutrophil infiltration into the lungs seems to be related to the release of systemic and local mediators. The liver and alveolar macrophages are sources of mediators that have been suggested to participate in the lung damage associated with AP.
methodsPancreatitis was induced in rats by intraductal administration of 5% sodium taurocholate. The inflammatory process in the lung and the activation of alveolar macrophages were investigated in animals with and without portocaval shunting 3 hours after AP induction. Alveolar macrophages were obtained by bronchoalveolar lavage. The generation of nitric oxide, leukotriene B4, tumor necrosis factor-alpha, and MIP-2 by alveolar macrophages and the chemotactic activity of supernatants of cultured macrophages were evaluated.
resultsPancreatitis was associated with increased infiltration of neutrophils into the lungs 3 hours after induction. This effect was prevented by the portocaval shunt. Alveolar macrophages obtained after induction of pancreatitis generated increased levels of nitric oxide, tumor necrosis factor-alpha, and MIP-2, but not leukotriene B4. In addition, supernatants of these macrophages exhibited a chemotactic activity for neutrophils when instilled into the lungs of unmanipulated animals. All these effects were abolished when portocaval shunting was carried out before induction of pancreatitis.
conclusionLung damage induced by experimental AP is associated with alveolar macrophage activation. The liver mediates the alveolar macrophage activation in this experimental model.
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