ArticleOncogene1999
Diverse developing mouse lineages exhibit high-level c-Myb expression in immature cells and loss of expression upon differentiation.
Article in Oncogene, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 58 citations in OpenAlex.
- Article
- Expression dynamics of metalloproteinases during mandibular bone formation: association with Myb transcription factor.Frontiers in cell and developmental biology · 2023Article
- MYB oncoproteins: emerging players and potential therapeutic targets in human cancer.Oncogenesis · 2021Review
- Overexpression of MYB in the Skin Induces Alopecia and Epidermal Hyperplasia.The Journal of investigative dermatology · 2020Article
- Sex-determining region Y (SRY) attributes to gender differences in RANKL expression and incidence of osteoporosis.Experimental & molecular medicine · 2019Article
- Transcription regulation ofAnnals of translational medicine · 2018Review
- Article
- CDK9 inhibitors selectively target estrogen receptor-positive breast cancer cells through combined inhibition of MYB and MCL-1 expression.Oncotarget · 2016Article
- Myb permits multilineage airway epithelial cell differentiation.Stem cells (Dayton, Ohio) · 2014Article
- Article
- c-Myb promotes the survival of CD4+CD8+ double-positive thymocytes through upregulation of Bcl-xL.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- MYB suppresses differentiation and apoptosis of human breast cancer cells.Breast cancer research : BCR · 2010Article
- Article
- Reduced c-myb expression levels affect hematopoietic development in vitro.International journal of hematology · 2007Article
- Ovol1 represses its own transcription by competing with transcription activator c-Myb and by recruiting histone deacetylase activity.Nucleic acids research · 2007Article
- Selective inhibition of c-Myb DNA-binding by RNA polymers.BMC biochemistry · 2004Article
- Progression through key stages of haemopoiesis is dependent on distinct threshold levels of c-Myb.The EMBO journal · 2003Article
- Article
- A Myb dependent pathway maintains Friend murine erythroleukemia cells in an immature and proliferating state.Oncogene · 2002Article
- The upstream enhancer is necessary and sufficient for the expression of the pre-T cell receptor alpha gene in immature T lymphocytes.The Journal of experimental medicine · 2001Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
The c-myb gene encodes a sequence specific transactivator that is required for fetal hematopoiesis, but its potential role in other tissues is less clear because of the early fetal demise of mice with targeted deletions of the c-myb gene and incomplete of knowledge about c-myb's expression pattern. In the hematopoietic system, c-Myb protein acts on target genes whose expression is restricted to individual lineages, despite Myb's presence and role in multiple immature lineages. This suggests that c-Myb actions within different cell type-specific contexts are strongly affected by combinatorial interactions. To consider the possibility of similar c-Myb actions could extend into non-hematopoietic systems in other cell and tissue compartments, we characterized c-myb expression in developing and adult mice using in situ hybridization and correlated this with stage-specific differentiation and mitotic activity. Diverse tissues exhibited strong c-myb expression during development, notably tooth buds, the thyroid primordium, developing trachea and proximal branching airway epithelium, hair follicles, hematopoietic cells, and gastrointestinal crypt epithelial cells. The latter three of these all maintained high expression into adulthood, but with characteristic restriction to immature cell lineages prior to their terminal differentiation. In all sites, during fetal and adult stages, loss of c-Myb expression correlated strikingly with the initiation of terminal differentiation, but not the loss of mitotic activity. Based on these data, we hypothesize that c-Myb's function during cellular differentiation is both an activator of immature gene expression and a suppressor of terminal differentiation in diverse lineages.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.