ArticleOncogene1999
Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105.
Article in Oncogene, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- LYL1 is critical for adult hematopoietic stem cell-derived B and T lymphopoiesis.Scientific reports · 2026Article
- Functional circuits of LYL1 controlled by supraphysiological androgen in prostate cancer cells to regulate cell senescence.Cell communication and signaling : CCS · 2024Article
- Lyl1-deficiency promotes inflammatory responses and increases mycobacterial burden in response toFrontiers in immunology · 2022Article
- Lyl-1 regulates primitive macrophages and microglia development.Communications biology · 2021Article
- Prognostic Significance of the Lymphoblastic Leukemia-Derived Sequence 1 (LYL1) GeneExpression in Egyptian Patients with AcuteMyeloid Leukemia.Turkish journal of haematology : official journal of Turkish Society of Haematology · 2014Article
- NFκB function and regulation in cutaneous T-cell lymphoma.American journal of cancer research · 2013Review
- NF-κB, the first quarter-century: remarkable progress and outstanding questions.Genes & development · 2012Review
- Crosstalk in NF-κB signaling pathways.Nature immunology · 2011Review
- Prostaglandin E receptor type 4-associated protein interacts directly with NF-kappaB1 and attenuates macrophage activation.The Journal of biological chemistry · 2008Article
- Overexpression of a transcription factor LYL1 induces T- and B-cell lymphoma in mice.Oncogene · 2007Article
- The 20S proteasome processes NF-kappaB1 p105 into p50 in a translation-independent manner.The EMBO journal · 2006Article
- Article
- Specific NEMO mutations impair CD40-mediated c-Rel activation and B cell terminal differentiation.The Journal of clinical investigation · 2004Article
- Functions of NF-kappaB1 and NF-kappaB2 in immune cell biology.The Biochemical journal · 2004Review
- Cell surface CCR5 density determines the postentry efficiency of R5 HIV-1 infection.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- RelB-p50 NF-kappa B complexes are selectively induced by cytomegalovirus immediate-early protein 1: differential regulation of Bcl-x(L) promoter activity by NF-kappa B family members.Journal of virology · 2002Article
- Review
- The RelA NF-kappaB subunit and the aryl hydrocarbon receptor (AhR) cooperate to transactivate the c-myc promoter in mammary cells.Oncogene · 2000Article
- Aberrant rel/nfkb genes and activity in human cancer.Oncogene · 1999Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The LYL1 gene was first identified upon the molecular characterization of the t(7;9)(q35;p13) translocation associated with some human T-cell acute leukemias (T-ALLs). In adult tissues, LYL1 expression is restricted to hematopoietic cells with the notable exclusion of the T cell lineage. LYL1 encodes a basic helix-loop-helix (bHLH) protein highly related to TAL-1, whose activation is also associated with a high proportion of human T-ALLs. A yeast two-hybrid system was used to identify proteins that specifically interact with LYL1 and might mediate its activities. We found that p105, the precursor of NF-kappaB1 p50, was the major LYL1-interacting protein in this system. The association between LYL1 and p105 was confirmed both in vitro and in vivo in mammalian cells. Biochemical studies indicated that the interaction was mediated by the bHLH motif of LYL1 and the ankyrin-like motifs of p105. Ectopic expression of LYL1 in a human T cell line caused a significant decrease in NF-kappaB-dependent transcription, associated with a reduced level of NF-kappaB1 proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.