Trial reportJournal of clinical pathology1998
Hybrid capture II, a new sensitive test for human papillomavirus detection. Comparison with hybrid capture I and PCR results in cervical lesions.
Trial report in Journal of clinical pathology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 137 citations in OpenAlex.
- A Holistic Framework for Cervical Cancer Screening and Risk Stratification: Integrating Etiology, Morphology, Epigenetics, and Microecology.Cancer management and research · 2026Review
- HPV infection and its correlation with p53 and Bcl-2 among pregnant mothers and their infants.Virus genes · 2024Article
- Can HPV Test on Random Urine Replace Self-HPV Test on Vaginal Self-Samples or Clinician-Collected Cervical Samples?International journal of women's health · 2023Article
- Single type infection of human papillomavirus as a cause for high-grade cervical intraepithelial neoplasia and invasive cancer in Japan.Papillomavirus research (Amsterdam, Netherlands) · 2018Article
- Correlation between Human Papillomavirus Status and Quantitative MR Imaging Parameters including Diffusion-Weighted Imaging and Texture Features in Oropharyngeal Carcinoma.AJNR. American journal of neuroradiology · 2018Article
- Molecular mechanisms of the preventable causes of cancer in the United States.Genes & development · 2018Review
- Dynamic response of HPV16/anti-HPV16 pairs with unbinding events studied by atomic force microscopy.Biochemistry and biophysics reports · 2016Article
- Hybrid Capture 2 is as effective as PCR testing for high-risk human papillomavirus in head and neck cancers.Applied immunohistochemistry & molecular morphology : AIMM · 2015Article
- Limitations of widely used high-risk human papillomavirus laboratory-developed testing in cervical cancer screening.Drug, healthcare and patient safety · 2012Article
- Anal cancer in renal transplant patients.International journal of colorectal disease · 2007Review
- Comparison between prototype hybrid capture 3 and hybrid capture 2 human papillomavirus DNA assays for detection of high-grade cervical intraepithelial neoplasia and cancer.Journal of clinical microbiology · 2003Article
- Papanicolaou tests and molecular analyses using new fluid-based specimen collection technology in 3000 Japanese women.British journal of cancer · 2003Article
- Cervical cancer.Journal of clinical pathology · 2002Article
- Human papillomavirus testing in primary screening for the detection of high-grade cervical lesions: a study of 7932 women.British journal of cancer · 2001Article
- A longitudinal study of HPV detection and cervical pathology in HIV infected women.Sexually transmitted infections · 2000Article
- Hybrid Capture II-based human papillomavirus detection, a sensitive test to detect in routine high-grade cervical lesions: a preliminary study on 1518 women.British journal of cancer · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo test a new assay for the detection of human papillomavirus (HPV) DNA, hybrid capture II (HC II), compared with the previous commercialized hybrid capture I (HC I) and polymerase chain reaction (PCR) results on cervical scrapes from fresh cone excision biopsy samples.
methodsThe three methods were used on cervical scrapes from 42 fresh cone excision biopsy samples. There were nine metaplastic and inflammatory lesions, five low grade lesions, and 28 high grade lesions. PCR was performed using the general primers GP5+/GP6+. The viral load of high risk HPV DNA was estimated by the ratio of relative light units to positive control values in the samples.
resultsThe sensitivity of HC I for the detection of high grade lesions was 71.4%, while it was 92.8% for HC II and 96.4% for the PCR. Considering only the absence of detectable cervical in situ neoplasia, the specificity was 88.9% for HC I, 66.7% for HC II, and 66.7% for PCR. With HC II, for a ratio of cervical sample to normal control of > 200, the sensitivity for the detection of high grade lesion was only 34.6% with a specificity of 66.7%.
conclusionsHPV detection with the HC II assay is more sensitive than the previous HC I and represents a more convenient and easier test than PCR for routine use. Nevertheless the viral load estimated with this test cannot be a reliable predictive indicator of high grade lesions.
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