ArticleGenome research1999
The mouse Aire gene: comparative genomic sequencing, gene organization, and expression.
Article in Genome research, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 78 citations in OpenAlex.
- Review
- The CRISPR-Cas9 System Is Used to Edit the Autoimmune Regulator Gene in Vitro and in Vivo.Advances in experimental medicine and biology · 2025Article
- A partial form of AIRE deficiency underlies a mild form of autoimmune polyendocrine syndrome type 1.The Journal of clinical investigation · 2023Article
- Characterisation of APS-1 Experimental Models Is Crucial for Development of Novel Therapies.BioMed research international · 2023Article
- Review
- The AIRE G228W mutation disturbs the interaction of AIRE with its partner molecule SIRT1.Frontiers in immunology · 2022Article
- B Cells and Autoantibodies in AIRE Deficiency.Biomedicines · 2021Review
- The Role of AIRE Deficiency in Infertility and Its Potential Pathogenesis.Frontiers in immunology · 2021Review
- Autoimmune Addison's Disease as Part of the Autoimmune Polyglandular Syndrome Type 1: Historical Overview and Current Evidence.Frontiers in immunology · 2021Review
- AAV9-mediated AIRE gene delivery clears circulating antibodies and tissue T-cell infiltration in a mouse model of autoimmune polyglandular syndrome type-1.Clinical & translational immunology · 2020Article
- Aire Gene Influences the Length of the 3' UTR of mRNAs in Medullary Thymic Epithelial Cells.Frontiers in immunology · 2020Article
- Update on Aire and thymic negative selection.Immunology · 2018Review
- Twenty Years of AIRE.Frontiers in immunology · 2018Review
- AIRE polymorphism, melanoma antigen-specific T cell immunity, and susceptibility to melanoma.Oncotarget · 2016Article
- Intronic regulation of Aire expression by Jmjd6 for self-tolerance induction in the thymus.Nature communications · 2015Article
- AIRE acetylation and deacetylation: effect on protein stability and transactivation activity.Journal of biomedical science · 2014Article
- Human APECED; a Sick Thymus Syndrome?Frontiers in immunology · 2013Review
- Expression of the autoimmune regulator gene and its relevance to the mechanisms of central and peripheral tolerance.Clinical & developmental immunology · 2012Review
- Expression and function of the autoimmune regulator (Aire) gene in non-thymic tissue.Clinical and experimental immunology · 2011Review
- AIRE in the thymus and beyond.Current opinion in immunology · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mutations in the human AIRE gene (hAIRE) result in the development of an autoimmune disease named APECED (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy; OMIM 240300). Previously, we have cloned hAIRE and shown that it codes for a putative transcription-associated factor. Here we report the cloning and characterization of Aire, the murine ortholog of hAIRE. Comparative genomic sequencing revealed that the structure of the AIRE gene is highly conserved between human and mouse. The conceptual proteins share 73% homology and feature the same typical functional domains in both species. RT-PCR analysis detected three splice variant isoforms in various mouse tissues, and interestingly one isoform was conserved in human, suggesting potential biological relevance of this product. In situ hybridization on mouse and human histological sections showed that AIRE expression pattern was mainly restricted to a few cells in the thymus, calling for a tissue-specific function of the gene product.
Indexed as
Identifiers
10022980PMC310712W1671992173What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.