ArticleMolecular and cellular biology1999
Neu differentiation factor stimulates phosphorylation and activation of the Sp1 transcription factor.
Article in Molecular and cellular biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- An Integrated Molecular Analysis of Lung Adenocarcinomas Identifies Potential Therapeutic Targets among TTF1-Negative Tumors, Including DNA Repair Proteins and Nrf2.Clinical cancer research : an official journal of the American Association for Cancer Research · 2015Article
- Transcription of the vascular endothelial growth factor receptor-3 (VEGFR3) gene is regulated by the zinc finger proteins Sp1 and Sp3 and is under epigenetic control: transcription of vascular endothelial growth factor receptor 3.Cellular oncology (Dordrecht, Netherlands) · 2014Article
- Androgen receptor signaling and mutations in prostate cancer.Asian journal of andrology · 2010Review
- FOXO3a mediates signaling crosstalk that coordinates ubiquitin and atrogin-1/MAFbx expression during glucocorticoid-induced skeletal muscle atrophy.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010Article
- Regulation of transcription factors and repression of Sp1 by prolactin signaling through the short isoform of its cognate receptor.Endocrinology · 2009Article
- PMA stimulates MUC5B gene expression through an Sp1-based mechanism in airway epithelial cells.American journal of respiratory cell and molecular biology · 2007Article
- Roles for neuregulins in human cancer.Clinical & experimental metastasis · 2004Review
- A novel pathway for MuSK to induce key genes in neuromuscular synapse formation.The Journal of cell biology · 2003Article
- Differential regulation of tumor angiogenesis by distinct ErbB homo- and heterodimers.Molecular biology of the cell · 2002Article
- Expression of mutant Ets protein at the neuromuscular synapse causes alterations in morphology and gene expression.EMBO reports · 2002Article
- Erk5 participates in neuregulin signal transduction and is constitutively active in breast cancer cells overexpressing ErbB2.Molecular and cellular biology · 2002Article
- Autostimulation of the Epstein-Barr virus BRLF1 promoter is mediated through consensus Sp1 and Sp3 binding sites.Journal of virology · 2001Article
- Exonic Sp1 sites are required for neural-specific expression of the glycine receptor beta subunit gene.The Biochemical journal · 2001Article
- Grb2 and Shc adapter proteins play distinct roles in Neu (ErbB-2)-induced mammary tumorigenesis: implications for human breast cancer.Molecular and cellular biology · 2001Article
- Sp1 phosphorylation regulates inducible expression of platelet-derived growth factor B-chain gene via atypical protein kinase C-zeta.Nucleic acids research · 2001Article
- Review
- Tea polyphenols down-regulate the expression of the androgen receptor in LNCaP prostate cancer cells.Oncogene · 2000Article
- Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway.Molecular and cellular biology · 2000Article
- Identification by in vivo genomic footprinting of a transcriptional switch containing NF-kappaB and Sp1 that regulates the IkappaBalpha promoter.Molecular and cellular biology · 1999Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Neu differentiation factors (NDFs), or neuregulins, are epidermal growth factor-like growth factors which bind to two tyrosine kinase receptors, ErbB-3 and ErbB-4. The transcription of several genes is regulated by neuregulins, including genes encoding specific subunits of the acetylcholine receptor at the neuromuscular junction. Here, we have examined the promoter of the acetylcholine receptor epsilon subunit and delineated a minimal CA-rich sequence which mediates transcriptional activation by NDF (NDF-response element [NRE]). Using gel mobility shift analysis with an NRE oligonucleotide, we detected two complexes that are induced by treatment with neuregulin and other growth factors and identified Sp1, a constitutively expressed zinc finger phosphoprotein, as a component of one of these complexes. Phosphatase treatment, two-dimensional gel electrophoresis, and an in-gel kinase assay indicated that Sp1 is phosphorylated by a 60-kDa kinase in response to NDF-induced signals. Moreover, Sp1 seems to act downstream of all members of the ErbB family and thus may funnel the signaling of the ErbB network into the nucleus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.