ArticleMolecular and cellular biology1999
A low-affinity serum response element allows other transcription factors to activate inducible gene expression in cardiac myocytes.
Article in Molecular and cellular biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed, 26 citations in OpenAlex.
- Degeneration of the mouse retina upon dysregulated activity of serum response factor.Molecular vision · 2011Article
- MURC, a muscle-restricted coiled-coil protein that modulates the Rho/ROCK pathway, induces cardiac dysfunction and conduction disturbance.Molecular and cellular biology · 2008Article
- Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin.Molecular and cellular biology · 2005Article
- Target gene-specific modulation of myocardin activity by GATA transcription factors.Molecular and cellular biology · 2004Article
- Myocardin expression is regulated by Nkx2.5, and its function is required for cardiomyogenesis.Molecular and cellular biology · 2003Article
- Serum response factor is crucial for actin cytoskeletal organization and focal adhesion assembly in embryonic stem cells.The Journal of cell biology · 2002Article
- Use of chromatin immunoprecipitation to clone novel E2F target promoters.Molecular and cellular biology · 2001Article
- The neuron-restrictive silencer element-neuron-restrictive silencer factor system regulates basal and endothelin 1-inducible atrial natriuretic peptide gene expression in ventricular myocytes.Molecular and cellular biology · 2001Article
- Serum response factor-GATA ternary complex required for nuclear signaling by a G-protein-coupled receptor.Molecular and cellular biology · 2001Article
- Regulation of mitogen-activated protein kinases in cardiac myocytes through the small G protein Rac1.Molecular and cellular biology · 2001Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Hypertrophic growth of cardiac muscle cells is induced by a variety of physiological and pathological stimuli and is associated with a number of changes, including activation of genes such as atrial natriuretic factor. We found that two serum response element (SRE)-like DNA elements, one of which does not meet the consensus sequence and binds serum response factor (SRF) with low affinity, regulate the activity of this promoter. Surprisingly, the ability to induce the promoter by two different physiologic stimuli, as well as various activated transcription factors, including SRF-VP16, was primarily dependent upon the nonconsensus rather than the consensus SRE. This SRE controls the induction of gene expression via an unusual mechanism in that it is required to allow some, but not all, active transcription factors at unrelated sites on the promoter to stimulate gene expression. Thus, in addition to regulation of SRF activity by growth stimuli, regulation of a low-affinity SRE element controls inducible gene expression by modulating the ability of other transcription factors to stimulate the transcription machinery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.