ArticleMolecular and cellular biology1999
The histone acetylase PCAF is a phorbol-ester-inducible coactivator of the IRF family that confers enhanced interferon responsiveness.
Article in Molecular and cellular biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 137 citations in OpenAlex.
- Mechanisms and progress of LncRNAs in prostate cancer development and diagnostic therapy.International urology and nephrology · 2025Review
- The pattern of histone H3 epigenetic posttranslational modifications is regulated by the VRK1 chromatin kinase.Epigenetics & chromatin · 2023Article
- Virtual ChIP-seq: predicting transcription factor binding by learning from the transcriptome.Genome biology · 2022Article
- Loss of Long Noncoding RNACancer research · 2022Article
- Complex functions of Gcn5 and Pcaf in development and disease.Biochimica et biophysica acta. Gene regulatory mechanisms · 2021Review
- The macrophage IRF8/IRF1 regulome is required for protection against infections and is associated with chronic inflammation.The Journal of experimental medicine · 2016Article
- Endotoxin tolerance in monocytes can be mitigated by α2-interferon.Journal of leukocyte biology · 2015Article
- Intercellular interplay between Sirt1 signalling and cell metabolism in immune cell biology.Immunology · 2015Review
- Division of labor between IRF1 and IRF2 in regulating different stages of transcriptional activation in cellular antiviral activities.Cell & bioscience · 2015Article
- Interferon regulatory factor 1 and histone H4 acetylation in systemic lupus erythematosus.Epigenetics · 2015Article
- A distal locus element mediates IFN-γ priming of lipopolysaccharide-stimulated TNF gene expression.Cell reports · 2014Article
- Review
- IκB kinase ε targets interferon regulatory factor 1 in activated T lymphocytes.Molecular and cellular biology · 2014Article
- RNA-dependent dynamic histone acetylation regulates MCL1 alternative splicing.Nucleic acids research · 2014Article
- Histone deacetylase sirtuin 1 deacetylates IRF1 protein and programs dendritic cells to control Th17 protein differentiation during autoimmune inflammation.The Journal of biological chemistry · 2013Article
- Inhibition of pyrimidine biosynthesis pathway suppresses viral growth through innate immunity.PLoS pathogens · 2013Article
- A multiprotein binding interface in an intrinsically disordered region of the tumor suppressor protein interferon regulatory factor-1.The Journal of biological chemistry · 2011Article
- Histone acetyltransferases as regulators of nonhistone proteins: the role of interferon regulatory factor acetylation on gene transcription.Journal of biomedicine & biotechnology · 2011Review
- The novel p53 target gene IRF2BP2 participates in cell survival during the p53 stress response.Nucleic acids research · 2009Article
- Altered memory capacities and response to stress in p300/CBP-associated factor (PCAF) histone acetylase knockout mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2008Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcription factors of the interferon regulatory factor (IRF) family bind to the type I interferon (IFN)-responsive element (ISRE) and activate transcription from IFN-inducible genes. To identify cofactors that associate with IRF proteins, DNA affinity binding assays were performed with nuclear extracts prepared from tissue culture cells. The results demonstrated that the endogenous IRFs bound to the ISRE are complexed with the histone acetylases, PCAF, GCN5, and p300/CREB binding protein and that histone acetylase activities are accumulated on the IRF-ISRE complexes. By testing recombinant proteins, we show that PCAF directly binds to some but not all members of the IRF family through distinct domains of the two proteins. This interaction was functionally significant, since transfection of PCAF strongly enhanced IRF-1- and IRF-2-dependent promoter activities. Further studies showed that expression of PCAF and other histone acetylases was markedly induced in U937 cells upon phorbol ester treatment, which led to increased recruitment of PCAF to the IRF-ISRE complexes. Coinciding with the induction of histone acetylases, phorbol ester markedly enhanced IFN-alpha-stimulated gene expression in U937 cells. Supporting the role for PCAF in conferring IFN responsiveness, transfection of PCAF into U937 cells led to a large increase in IFN-alpha-inducible promoter activity. These results demonstrate that PCAF is a phorbol ester-inducible coactivator of the IRF proteins which contributes to the establishment of type I IFN responsiveness.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.