ArticleThe EMBO journal1999
The role of RBF in the introduction of G1 regulation during Drosophila embryogenesis.
Article in The EMBO journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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Who cites it
63 citing papers in PubMed, 115 citations in OpenAlex.
- Clinical and genetic characterization of a progressive RBL2-associated neurodevelopmental disorder.Brain : a journal of neurology · 2025Article
- The Krüppel-like factor Cabut has cell cycle regulatory properties similar to E2F1.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Rb family-independent activating E2F increases genome stability, promotes homologous recombination, and decreases non-homologous end joining.Mechanisms of development · 2020Article
- Changes in chromatin accessibility ensure robust cell cycle exit in terminally differentiated cells.PLoS biology · 2019Article
- Rbf Activates the Myogenic Transcriptional Program to Promote Skeletal Muscle Differentiation.Cell reports · 2019Article
- Diagnosis of the OCD Patients using Drawing Features of the Bender Gestalt Shapes.Journal of biomedical physics & engineering · 2017Article
- Rbf Regulates Drosophila Spermatogenesis via Control of Somatic Stem and Progenitor Cell Fate in the Larval Testis.Stem cell reports · 2016Article
- The pro-apoptotic activity of Drosophila Rbf1 involves dE2F2-dependent downregulation of diap1 and buffy mRNA.Cell death & disease · 2014Article
- dREAM co-operates with insulator-binding proteins and regulates expression at divergently paired genes.Nucleic acids research · 2014Article
- Hyperactivated Wnt signaling induces synthetic lethal interaction with Rb inactivation by elevating TORC1 activities.PLoS genetics · 2014Article
- Mutating RBF can enhance its pro-apoptotic activity and uncovers a new role in tissue homeostasis.PloS one · 2014Article
- The components of Drosophila histone chaperone dCAF-1 are required for the cell death phenotype associated with rbf1 mutation.G3 (Bethesda, Md.) · 2013Article
- Capicua regulates proliferation and survival of RB-deficient cells in Drosophila.Biology open · 2013Article
- Loss of RBF1 changes glutamine catabolism.Genes & development · 2013Article
- The molecular chaperone Hsp90 is required for cell cycle exit in Drosophila melanogaster.PLoS genetics · 2013Article
- Ubiquitination of retinoblastoma family protein 1 potentiates gene-specific repression function.The Journal of biological chemistry · 2012Article
- Evidence for autoregulation and cell signaling pathway regulation from genome-wide binding of the Drosophila retinoblastoma protein.G3 (Bethesda, Md.) · 2012Article
- RBF binding to both canonical E2F targets and noncanonical targets depends on functional dE2F/dDP complexes.Molecular and cellular biology · 2012Article
- S phase-coupled E2f1 destruction ensures homeostasis in proliferating tissues.PLoS genetics · 2012Article
- Autoregulation of the Drosophila Noncoding roX1 RNA Gene.PLoS genetics · 2012Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The first appearance of G1 during Drosophila embryogenesis, at cell cycle 17, is accompanied by the down-regulation of E2F-dependent transcription. Mutant alleles of rbf were generated and analyzed to determine the role of RBF in this process. Embryos lacking both maternal and zygotic RBF products show constitutive expression of PCNA and RNR2, two E2F-regulated genes, indicating that RBF is required for their transcriptional repression. Despite the ubiquitous expression of E2F target genes, most epidermal cells enter G1 normally. Rather than pausing in G1 until the appropriate time for cell cycle progression, many of these cells enter an ectopic S-phase. These results indicate that the repression of E2F target genes by RBF is necessary for the maintenance but not the initiation of a G1 phase. The phenotype of RBF-deficient embryos suggests that rbf has a function that is complementary to the roles of dacapo and fizzy-related in the introduction of G1 during Drosophila embryogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.