ArticleThe EMBO journal1999
Inward rectification in KATP channels: a pH switch in the pore.
Article in The EMBO journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 85 citations in OpenAlex.
- Glycolytic activation of β-cell NaMolecular metabolism · 2026Article
- Intracellular pH regulates the strength of the intrinsic inward rectification of Kir4.1/Kir5.1 channels.Pflugers Archiv : European journal of physiology · 2025Article
- High lactic acid levels in the brain contribute to the generation of focal slowing on the electroencephalogram.Frontiers in neurology · 2024Review
- RNA-Seq Analyses Reveal Roles of the HVCN1 Proton Channel in Cardiac pH Homeostasis.Frontiers in cell and developmental biology · 2022Article
- Kir Channel Molecular Physiology, Pharmacology, and Therapeutic Implications.Handbook of experimental pharmacology · 2021Review
- Lactate activation of α-cell KMolecular metabolism · 2020Article
- Ammonium and nitrate regulate NH4+ uptake activity of Arabidopsis ammonium transporter AtAMT1;3 via phosphorylation at multiple C-terminal sites.Journal of experimental botany · 2019Article
- Article
- Mechanism of inhibition of mouse Slo3 (KCa 5.1) potassium channels by quinine, quinidine and barium.British journal of pharmacology · 2015Article
- Isolation and functional characterization of a high affinity urea transporter from roots of Zea mays.BMC plant biology · 2014Article
- Control of KirBac3.1 potassium channel gating at the interface between cytoplasmic domains.The Journal of biological chemistry · 2014Article
- Article
- Single K ATP channel opening in response to action potential firing in mouse dentate granule neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Functional properties of the Arabidopsis peptide transporters AtPTR1 and AtPTR5.The Journal of biological chemistry · 2010Article
- A dual mechanism of cytoprotection afforded by M-LDH in embryonic heart H9C2 cells.Biochimica et biophysica acta · 2009Article
- Incomplete dissociation of glibenclamide from wild-type and mutant pancreatic K ATP channels limits their recovery from inhibition.British journal of pharmacology · 2009Article
- Nitrogen affects cluster root formation and expression of putative peptide transporters.Journal of experimental botany · 2009Article
- Identification of a pH sensor in the furin propeptide that regulates enzyme activation.The Journal of biological chemistry · 2006Article
- AtGAT1, a high affinity transporter for gamma-aminobutyric acid in Arabidopsis thaliana.The Journal of biological chemistry · 2006Article
- Molecular diversity and regulation of renal potassium channels.Physiological reviews · 2005Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inward-rectifier potassium channels (Kir channels) stabilize the resting membrane potential and set a threshold for excitation in many types of cell. This function arises from voltage-dependent rectification of these channels due to blockage by intracellular polyamines. In all Kir channels studied to date, the voltage-dependence of rectification is either strong or weak. Here we show that in cardiac as well as in cloned KATP channels (Kir6.2 + sulfonylurea receptor) polyamine-mediated rectification is not fixed but changes with intracellular pH in the physiological range: inward-rectification is prominent at basic pH, while at acidic pH rectification is very weak. The pH-dependence of polyamine block is specific for KATP as shown in experiments with other Kir channels. Systematic mutagenesis revealed a titratable C-terminal histidine residue (H216) in Kir6.2 to be the structural determinant, and electrostatic interaction between this residue and polyamines was shown to be the molecular mechanism underlying pH-dependent rectification. This pH-dependent block of KATP channels may represent a novel and direct link between excitation and intracellular pH.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.