ArticleThe Journal of clinical investigation1999
Analysis of the adult thymus in reconstitution of T lymphocytes in HIV-1 infection.
Article in The Journal of clinical investigation, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 200 citations in OpenAlex.
- The reconstitution of the thymus in immunosuppressed individuals restores CD4-specific cellular and humoral immune responses.Immunology · 2011Trial
- Decreased CD95 expression on naive T cells from HIV-infected persons undergoing highly active anti-retroviral therapy (HAART) and the influence of IL-2 low dose administration. Irhan Study Group.Clinical and experimental immunology · 2000Trial
- Sequential quantification of T-cell receptor excision circles (TRECs) and K-deleting recombination excision circles (KRECs) and overall survival after allogeneic HSCT.Bone marrow transplantation · 2026Article
- Pre-TCR-targeted immunotherapy for T cell acute lymphoblastic leukemia.Nature immunology · 2025Article
- The other pandemic: lessons from 40 years of HIV research.The Journal of clinical investigation · 2024Article
- Impact ofFrontiers in microbiology · 2023Article
- Article
- Casp8p41: The Protean Mediator of Death in CD4 T-cells that Replicate HIV.Journal of cell death · 2016Review
- Thymic HIV-2 infection uncovers posttranscriptional control of viral replication in human thymocytes.Journal of virology · 2015Article
- Primate lentiviral Nef proteins deregulate T-cell development by multiple mechanisms.Retrovirology · 2013Article
- The enduring tale of T cells in HIV immunopathogenesis.The Indian journal of medical research · 2013Review
- HIV pathogenesis: the host.Cold Spring Harbor perspectives in medicine · 2012Review
- CD4+ T cell depletion in human immunodeficiency virus (HIV) infection: role of apoptosis.Viruses · 2011Review
- CD4+ T cell depletion, immune activation and increased production of regulatory T cells in the thymus of HIV-infected individuals.PloS one · 2010Article
- The effect of aging, nutrition, and exercise during HIV infection.HIV/AIDS (Auckland, N.Z.) · 2010Article
- Polyclonal B cell differentiation and loss of gastrointestinal tract germinal centers in the earliest stages of HIV-1 infection.PLoS medicine · 2009Article
- Longitudinal analysis of immune function in the first 3 years of life in thymectomized neonates during cardiac surgery.Clinical and experimental immunology · 2008Article
- Growth hormone resurrects adult human thymus during HIV-1 infection.The Journal of clinical investigation · 2008Article
- Human T cell reconstitution in DiGeorge syndrome and HIV-1 infection.Seminars in immunology · 2007Review
- Immune reconstitution after allogeneic stem cell transplantation with reduced-intensity conditioning regimens.Leukemia · 2007Review
Corrections and comments
- Erratum issued
Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
A key question in understanding the status of the immune system in HIV-1 infection is whether the adult thymus contributes to reconstitution of peripheral T lymphocytes. We analyzed the thymus in adult patients who died of HIV-1 infection. In addition, we studied the clinical course of HIV-1 infection in three patients thymectomized for myasthenia gravis and determined the effect of antiretroviral therapy on CD4(+) T cells. We found that five of seven patients had thymus tissue at autopsy and that all thymuses identified had inflammatory infiltrates surrounding lymphodepleted thymic epithelium. Two of seven patients also had areas of thymopoiesis; one of these patients had peripheral blood CD4(+) T-cell levels of <50/mm3 for 51 months prior to death. Of three thymectomized patients, one rapidly progressed to AIDS, one progressed to AIDS over seven years (normal progressor), whereas the third remains asymptomatic at least seven years after seroconversion. Both latter patients had rises in peripheral blood CD4(+) T cells after antiretroviral therapy. Most patients who died of complications of HIV-1 infection did not have functional thymus tissue, and when present, thymopoiesis did not prevent prolonged lymphopenia. Thymectomy before HIV-1 infection did not preclude either peripheral CD4(+) T-cell rises or clinical responses after antiretroviral therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.