Status of gene therapy for cystic fibrosis lung disease.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

27 citing papers in PubMed, 138 citations in OpenAlex.

1. Artificial intelligence-guided design of lipid nanoparticles for pulmonary gene therapy.Nature biotechnology · 2025
   Article
2. An Intriguing Involvement of Mitochondria in Cystic Fibrosis.Journal of clinical medicine · 2019
   Review
3. Physiological study of pulmonary involvement in adults with cystic fibrosis through simulated modeling of different clinical scenarios.Medical & biological engineering & computing · 2019
   Article
4. Pseudomonas aeruginosa infection in cystic fibrosis lung disease and new perspectives of treatment: a review.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2013
   Review
5. Gene therapy: light is finally in the tunnel.Protein & cell · 2011
   Review
6. The future of radiology.Rambam Maimonides medical journal · 2011
   Article
7. Common gene therapy viral vectors do not efficiently penetrate sputum from cystic fibrosis patients.PloS one · 2011
   Article
8. Vectors for airway gene delivery.The AAPS journal · 2007
   Review
9. Glycocalyx restricts adenoviral vector access to apical receptors expressed on respiratory epithelium in vitro and in vivo: role for tethered mucins as barriers to lumenal infection.Journal of virology · 2004
   Article
10. Lentivirus-mediated gene transfer to the respiratory epithelium: a promising approach to gene therapy of cystic fibrosis.Gene therapy · 2004
    Review
11. Protection of Cftr knockout mice from acute lung infection by a helper-dependent adenoviral vector expressing Cftr in airway epithelia.Proceedings of the National Academy of Sciences of the United States of America · 2003
    Article
12. Respiratory syncytial virus infection of human airway epithelial cells is polarized, specific to ciliated cells, and without obvious cytopathology.Journal of virology · 2002
    Article
13. Pegylated GL67 lipoplexes retain their gene transfection activity after exposure to components of CF mucus.Gene therapy · 2002
    Article
14. Gene therapy of cystic fibrosis: the glycofection approach.Glycoconjugate journal · 2001
    Review
15. Jaagsiekte sheep retrovirus Env protein stabilizes retrovirus vectors against inactivation by lung surfactant, centrifugation, and freeze-thaw cycling.Journal of virology · 2001
    Article
16. Gene therapy of cystic fibrosis (CF) airways: a review emphasizing targeting with lactose.Glycoconjugate journal · 2001
    Review
17. Recent advances in cystic fibrosis.Archives of disease in childhood · 2001
    Review
18. Chitosan as a nonviral gene delivery system. Structure-property relationships and characteristics compared with polyethylenimine in vitro and after lung administration in vivo.Gene therapy · 2001
    Article
19. Airway gene transfer in mouse nasal-airways: importance of identification of epithelial type for assessment of gene transfer.Gene therapy · 2000
    Article
20. Internalization of adenovirus by alveolar macrophages initiates early proinflammatory signaling during acute respiratory tract infection.Journal of virology · 2000
    Article

Corrections and comments

• Comment on
  The innate immune system in cystic fibrosis lung disease.1999
• Comment on
  The genesis of cystic fibrosis lung disease.1999

Authors and funding

1 author at 1 institution in 1 country.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as