.pvis{--pvis-mint:#b8c2ca;--pvis-coral:#f0a89c;--pvis-blue:#adccef;--pvis-lavender:#c7b7ed;--pvis-event:var(--pvis-blue);--pvis-rest:#687b91;color:var(--text,#ebf0f7);background:radial-gradient(at 90% 0,#b8c2ca09,#0000 40%);padding:23px 0 45px;font-size:14px;line-height:1.6}.pvis *,.pvis :before,.pvis :after{box-sizing:border-box}.pvis :where(h1,h2,h3,h4,p){margin:0}.pvis a{color:var(--pvis-mint);text-underline-offset:3px}.pvis button{font:inherit;cursor:pointer}.pvis :focus-visible{outline:2px solid var(--pvis-mint);outline-offset:5px}.pvis-wrap{width:min(1240px,100% - 64px);margin-inline:auto}.pvis-topline{color:var(--muted,#9cabc0);flex-wrap:wrap;justify-content:space-between;align-items:center;gap:12px 24px;font-size:12px;display:flex}.pvis-topline a{align-items:center;gap:7px;text-decoration:none;display:inline-flex}.pvis-record-links{flex-wrap:wrap;gap:10px 20px;display:flex}.pvis-eyebrow{color:var(--pvis-mint);text-transform:uppercase;letter-spacing:1.6px;font-size:11px}.pvis-header{padding:18px 0 13px}.pvis-header h1{font-family:var(--font-display),system-ui, sans-serif;max-width:58ch;margin-top:7px;font-size:clamp(30px,3.5vw,44px);font-weight:600;line-height:1.1}.pvis-scope{color:var(--muted,#9cabc0);flex-wrap:wrap;gap:7px 20px;margin-top:13px;font-size:11px;display:flex}.pvis-scope>span{align-items:center;gap:7px;display:inline-flex}.pvis-notice{color:var(--pvis-coral);border:1px solid #f0a89c77;border-radius:10px;margin-top:20px;padding:15px 18px}.pvis-coverage-gaps{border:1px solid #afa1e844;border-radius:12px;margin:0 0 18px;padding:14px 18px}.pvis-coverage-gaps summary{cursor:pointer;color:var(--pvis-lavender);flex-wrap:wrap;align-items:center;gap:9px;font-size:14px;display:flex}.pvis-coverage-gaps summary span{color:var(--muted,#9cabc0);margin-left:auto;font-size:12px}.pvis-coverage-gaps summary strong{font-weight:500}.pvis-coverage-gaps ul{padding-left:20px;font-size:13px;line-height:1.7}.pvis-coverage-gaps li+li{margin-top:9px}.pvis-section-head{border-top:1px solid var(--line,#233041);justify-content:space-between;align-items:baseline;gap:16px;padding-top:12px;display:flex}.pvis-section-head h2{text-transform:uppercase;letter-spacing:1px;font-size:12px;font-weight:500}.pvis-section-head p{color:var(--muted,#9cabc0);font-size:12px}.pvis-choices{grid-template-columns:repeat(auto-fit,minmax(150px,1fr));gap:8px;margin:10px 0 14px;display:grid}.pvis-choice{text-align:left;border:1px solid var(--line,#233041);color:var(--text,#ebf0f7);background:var(--panel,#0d1622);border-radius:10px;align-items:flex-start;gap:8px;min-width:0;padding:12px;display:flex}.pvis-choice:hover{background:var(--soft,#162230)}.pvis-choice[aria-pressed=true]{border-color:var(--pvis-mint);box-shadow:inset 0 -2px var(--pvis-mint);background:#b8c2ca0a}.pvis-choice>svg{color:var(--pvis-mint);flex-shrink:0;margin-top:2px}.pvis-choice>span{gap:3px;display:grid}.pvis-choice strong{font-size:12px;font-weight:500;line-height:1.4}.pvis-choice small{color:var(--muted,#9cabc0);font-size:11px}.pvis-choice em{color:var(--pvis-lavender);font-size:11px;font-style:normal}.pvis-panel{border:1px solid var(--line-strong,#354151);background:var(--panel,#0d1622);border-radius:18px;overflow:hidden}.pvis-panel-head{border-bottom:1px solid var(--line,#233041);padding:18px 26px}.pvis-panel-head h2{font-family:var(--font-display),system-ui, sans-serif;margin-top:5px;font-size:clamp(26px,2.5vw,32px);font-weight:600;line-height:1.15}.pvis-panel-head>p{color:var(--muted,#9cabc0);margin-top:6px;font-size:12px}.pvis-badges{flex-wrap:wrap;gap:7px;margin-top:13px;display:flex}.pvis-badges:empty{display:none}.pvis-badge{color:var(--pvis-blue);border:1px solid #adccef40;border-radius:100px;align-items:center;gap:6px;padding:3px 10px;font-size:10px;display:inline-flex}.pvis-design-result{grid-template-columns:.85fr 1.15fr;display:grid}.pvis-design{border-right:1px solid var(--line,#233041);padding:20px 25px}.pvis-result{min-width:0;padding:20px 26px}.pvis-step-heading{align-items:center;gap:9px;margin-bottom:12px;display:flex}.pvis-step-heading>span{border:1px solid var(--line-strong,#354151);width:25px;height:25px;color:var(--muted,#9cabc0);border-radius:50%;flex-shrink:0;justify-content:center;align-items:center;font-size:11px;display:flex}.pvis-step-heading h3{font-size:13px;font-weight:500}.pvis-population{justify-content:center;align-items:center;gap:15px;padding:17px 0;display:flex}.pvis-population>svg{color:var(--pvis-mint);flex-shrink:0}.pvis-population>div{gap:3px;display:grid}.pvis-population strong{font-size:28px;font-weight:400;line-height:1.2}.pvis-population span{color:var(--muted,#9cabc0);max-width:36ch;font-size:12px}.pvis-assignment{text-align:center;flex-direction:column;align-items:center;padding:20px 8px 24px;display:flex;position:relative}.pvis-assignment:before{content:"";border-left:1px solid var(--line-strong,#354151);height:19px;position:absolute;top:0}.pvis-assignment>svg{color:var(--pvis-mint);box-sizing:content-box;border:1px solid #b8c2ca55;border-radius:9px;padding:7px}.pvis-assignment b{margin-top:9px;font-size:13px;font-weight:500}.pvis-assignment p{max-width:39ch;color:var(--muted,#9cabc0);margin-top:5px;font-size:11px}.pvis-groups{grid-template-columns:repeat(auto-fit,minmax(100px,1fr));gap:12px;padding-top:17px;display:grid;position:relative}.pvis-groups:before{content:"";border-top:1px solid var(--line-strong,#354151);position:absolute;top:0;left:15%;right:15%}.pvis-group{text-align:center;flex-direction:column;align-items:center;gap:5px;display:flex;position:relative}.pvis-group:before{content:"";border-left:1px solid var(--line-strong,#354151);height:13px;position:absolute;top:-17px}.pvis-group>svg{color:var(--pvis-lavender)}.pvis-group h4{font-size:13px;font-weight:500}.pvis-group strong{font-size:23px;font-weight:400}.pvis-group span{color:var(--muted,#9cabc0);font-size:11px}.pvis-time{color:var(--muted,#9cabc0);border-top:1px solid var(--line,#233041);align-items:flex-start;gap:9px;margin-top:24px;padding-top:16px;font-size:12px;display:flex}.pvis-time svg{color:var(--pvis-mint);flex-shrink:0;margin-top:2px}.pvis-design-note{color:var(--muted,#9cabc0);align-items:flex-start;gap:8px;font-size:11px;display:flex;margin-top:16px!important}.pvis-design-note svg{color:var(--pvis-lavender);flex-shrink:0}.pvis-result-intro{color:var(--muted,#9cabc0);font-size:12px;margin-bottom:16px!important}.pvis-counts{grid-template-columns:repeat(auto-fit,minmax(135px,1fr));gap:23px;display:grid}.pvis-safety-heading{margin:0 0 12px;font-size:16px}.pvis-safety-scope{color:#a5decd;border:1px solid #395b55;border-radius:6px;margin-bottom:18px;padding:6px 10px;font-size:12px;display:inline-block}.pvis-event-burden{border-top:1px solid var(--line,#233041);grid-template-columns:repeat(auto-fit,minmax(185px,1fr));gap:22px;margin-top:25px;padding-top:22px;display:grid}.pvis-burden-panel h4{align-items:center;gap:8px;margin-bottom:9px;font-size:14px;display:flex}.pvis-burden-panel>p{min-height:4em;color:var(--muted,#9cabc0);margin-bottom:18px;font-size:12px;line-height:1.6}.pvis-burden-row{margin:15px 0}.pvis-burden-row>div:first-child{justify-content:space-between;gap:12px;margin-bottom:6px;font-size:12px;display:flex}.pvis-burden-row strong{font-variant-numeric:tabular-nums;font-size:17px}.pvis-burden-track{background:var(--line,#233041);border-radius:3px;height:12px;overflow:hidden}.pvis-burden-track i{background:#65c9b6;border-radius:3px;height:100%;display:block}.pvis-burden-axis{color:var(--muted,#9cabc0);justify-content:space-between;gap:12px;font-size:10px;display:flex}.pvis-event-burden>.pvis-caption{grid-column:1/-1;margin:0}.pvis-count-group h4{min-height:2.1em;font-size:13px;font-weight:500}.pvis-count-number{align-items:baseline;gap:7px;display:flex}.pvis-count-number strong{font-size:35px;font-weight:400}.pvis-count-number span{color:var(--muted,#9cabc0);font-size:11px}.pvis-count-group>p{color:var(--muted,#9cabc0);margin-top:11px;font-size:11px}.pvis-count-picture{grid-template-columns:repeat(10,minmax(0,1fr));gap:3px 4px;max-width:200px;margin-top:9px;display:grid}.pvis-count-picture svg{width:100%;max-height:20px}.pvis-count-picture.is-unit{gap:4px}.pvis-count-picture.is-unit svg{max-height:12px}.pvis-count-key{color:var(--muted,#9cabc0);flex-wrap:wrap;gap:8px 16px;margin:15px 0 9px;font-size:11px;display:flex}.pvis-count-key>span{align-items:center;gap:6px;display:flex}.pvis-count-key i{background:var(--pvis-event);border-radius:2px;width:8px;height:10px}.pvis-count-key>span:last-child i{background:var(--pvis-rest)}.pvis-caption{color:var(--muted,#9cabc0);font-size:11px;line-height:1.65;margin-top:15px!important}.pvis-axis-direction{color:var(--muted,#9cabc0);justify-content:space-between;gap:16px;font-size:11px;display:flex}.pvis-interval-rows{margin-top:18px}.pvis-interval-row{padding-bottom:18px}.pvis-interval-label{flex-wrap:wrap;justify-content:space-between;align-items:baseline;gap:5px 15px;font-size:12px;display:flex}.pvis-interval-label b{font-weight:500}.pvis-interval-label>span{font-variant-numeric:tabular-nums}.pvis-interval-label small{color:var(--muted,#9cabc0);margin-left:5px;font-size:10px;display:inline-block}.pvis-measurement-detail{color:var(--muted,#9cabc0);margin:5px 0 0;font-size:12px;line-height:1.55}.pvis-interval-track{height:31px;margin-top:8px;position:relative}.pvis-track-line{background:var(--line-strong,#354151);height:3px;position:absolute;top:14px;left:4%;right:4%}.pvis-reference{border-left:1px dashed var(--muted,#9cabc0);height:31px;position:absolute;top:0}.pvis-interval-band{background:var(--pvis-event);height:4px;position:absolute;top:13px}.pvis-interval-band i{background:var(--pvis-event);width:2px;height:14px;position:absolute;top:-5px}.pvis-interval-band i:last-child{right:0}.pvis-estimate{background:var(--pvis-event);width:12px;height:12px;box-shadow:0 0 0 3px var(--panel,#0d1622);border-radius:50%;position:absolute;top:9px;transform:translate(-50%)}.pvis-estimate.is-pooled{border-radius:0;transform:translate(-50%)rotate(45deg)}.pvis-axis-ticks{height:28px;margin-top:-12px;position:relative}.pvis-axis-ticks>span{color:var(--muted,#9cabc0);white-space:nowrap;font-size:10px;position:absolute;transform:translate(-50%)}.pvis-plot-key{color:var(--muted,#9cabc0);flex-wrap:wrap;gap:8px 18px;margin-top:4px;font-size:10px;display:flex}.pvis-plot-key>span{align-items:center;gap:6px;display:flex}.pvis-plot-key i{background:var(--pvis-event)}.pvis-plot-key .is-point{border-radius:50%;width:7px;height:7px}.pvis-plot-key .is-line{width:17px;height:2px}.pvis-statistics{border-top:1px solid var(--line,#233041);padding:25px 30px}.pvis-statistic+.pvis-statistic{border-top:1px solid var(--line,#233041);margin-top:24px;padding-top:24px}.pvis-statistic>h4{margin-bottom:18px;font-size:13px;font-weight:500}.pvis-stat-readout{align-items:flex-start;gap:10px;margin-top:15px;font-size:13px;display:flex}.pvis-stat-readout svg{color:var(--pvis-mint);flex-shrink:0;margin-top:2px}.pvis-stat-summary{grid-template-columns:repeat(auto-fit,minmax(130px,1fr));gap:14px;display:grid}.pvis-stat-summary>div{border:1px solid var(--line,#233041);border-radius:10px;flex-direction:column;gap:5px;padding:18px;display:flex}.pvis-stat-summary strong{color:var(--pvis-blue);font-size:29px;font-weight:400}.pvis-stat-summary span{color:var(--muted,#9cabc0);font-size:11px}.pvis-missing{background:#9cabc005;border:1px dashed #9cabc066;border-radius:10px;gap:12px;margin-top:12px;padding:18px;display:flex}.pvis-missing>svg{color:var(--pvis-lavender);flex-shrink:0;margin-top:2px}.pvis-missing b{font-size:13px;font-weight:500}.pvis-missing p{color:var(--muted,#9cabc0);margin-top:5px;font-size:12px}.pvis-missing ul{color:var(--muted,#9cabc0);margin:8px 0 0;padding-left:18px;font-size:12px}.pvis-meaning{border-top:1px solid var(--line,#233041);grid-template-columns:1fr 1fr;display:grid}.pvis-meaning>div{padding:25px 30px}.pvis-meaning>div+div{border-left:1px solid var(--line,#233041)}.pvis-meaning h4{font-family:var(--font-display),system-ui, sans-serif;font-size:27px;font-weight:600;line-height:1.2}.pvis-meaning p{color:var(--muted,#9cabc0);margin-top:11px;font-size:12px}.pvis-limit-list{color:var(--muted,#9cabc0);margin:12px 0 0;padding-left:18px;font-size:12px}.pvis-limit-list li+li{margin-top:8px}.pvis-sources{flex-wrap:wrap;gap:8px 18px;margin-top:15px;font-size:11px;display:flex}.pvis-sources a{align-items:center;gap:4px;display:inline-flex}.pvis-source-trail{border-top:1px solid var(--line,#233041);padding:18px 30px;font-size:12px}.pvis-source-trail summary{cursor:pointer;color:var(--pvis-mint)}.pvis-source-trail ol{color:var(--muted,#9cabc0);padding-left:20px}.pvis-source-trail li{margin-top:14px}.pvis-source-trail blockquote{border-left:2px solid var(--line-strong,#354151);margin:8px 0;padding:6px 13px;font-size:11px}.pvis-source-trail small{color:var(--muted,#9cabc0);display:block}.pvis-diagnostic-grid{grid-template-columns:1fr 1fr;gap:10px;display:grid}.pvis-diagnostic-cell{border:1px solid var(--line-strong,#354151);border-radius:10px;flex-direction:column;gap:5px;padding:18px 14px;display:flex}.pvis-diagnostic-cell strong{font-size:29px;font-weight:400}.pvis-diagnostic-cell span{font-size:12px}.pvis-diagnostic-cell small{color:var(--muted,#9cabc0);font-size:10px}.pvis-diagnostic-cell.is-correct{border-color:#b8c2ca60}.pvis-diagnostic-cell.is-incorrect{border-color:#f0a89c70}.pvis-diagnostic-cell.is-correct strong{color:var(--pvis-mint)}.pvis-diagnostic-cell.is-incorrect strong{color:var(--pvis-coral)}.pvis-lab-flow{align-items:center;gap:12px;margin:20px 0;display:flex}.pvis-lab-flow>div{text-align:center;background:var(--soft,#162230);border-radius:12px;flex:1;padding:18px 12px}.pvis-lab-flow>div>svg{color:var(--pvis-lavender);margin-inline:auto}.pvis-lab-flow h4{margin-top:8px;font-size:13px;font-weight:500}.pvis-lab-flow p{color:var(--muted,#9cabc0);font-size:11px}.pvis-lab-flow>svg{color:var(--muted,#9cabc0);flex-shrink:0}.pvis-footer{color:var(--muted,#9cabc0);flex-wrap:wrap;justify-content:space-between;gap:12px;margin-top:25px;font-size:11px;display:flex}.pvis-chapters{grid-template-columns:repeat(5,minmax(0,1fr));gap:7px;margin:0 0 14px;display:grid}.pvis-chapters button{text-align:center;border:1px solid var(--line,#233041);color:var(--muted,#9cabc0);background:0 0;border-radius:9px;justify-content:center;align-items:center;gap:7px;padding:10px 7px;font-size:11px;display:flex}.pvis-chapters button>svg{flex-shrink:0}.pvis-chapters button:hover{background:var(--soft,#162230)}.pvis-chapters button[aria-pressed=true]{color:var(--pvis-mint);background:#b8c2ca08;border-color:#b8c2ca88}.pvis-partial-status{color:var(--muted,#9cabc0);margin:0 0 13px;font-size:11px}.pvis-partial-status summary{cursor:pointer;align-items:center;gap:7px;list-style:none;display:flex}.pvis-partial-status summary::-webkit-details-marker{display:none}.pvis-partial-status summary>svg{color:var(--pvis-lavender)}.pvis-partial-status ul{margin:8px 0;padding-left:21px}.pvis-selection-announcement{clip-path:inset(50%);white-space:nowrap;width:1px;height:1px;position:absolute;overflow:hidden}.pvis-stat-summary .pvis-word-value{font-size:20px;line-height:1.4}.pvis-context-only{gap:16px;display:grid}.pvis-study-context{grid-template-columns:repeat(auto-fit,minmax(min(100%,200px),1fr));gap:12px;padding:20px 26px;display:grid}.pvis-study-context>section{border:1px solid var(--line,#233041);background:var(--soft,#162230);border-radius:12px;min-width:0;padding:17px}.pvis-context-label{color:var(--pvis-mint);align-items:center;gap:9px;display:flex}.pvis-context-label>svg{flex-shrink:0}.pvis-context-label h3{font-size:12px;font-weight:500;line-height:1.4}.pvis-context-value{margin-top:14px}.pvis-context-value>p{overflow-wrap:anywhere;font-size:16px;line-height:1.4}.pvis-context-value .pvis-sources{margin-top:7px}.pvis-design>.pvis-study-context{padding:12px 0}.pvis-reported-metrics h4{font-size:14px;font-weight:500;line-height:1.4}.pvis-reported-metrics strong small{overflow-wrap:anywhere;font-size:15px}.pvis-reported-metrics .pvis-stat-summary{grid-template-columns:repeat(auto-fit,minmax(min(100%,180px),1fr))}.pvis-reported-metrics .pvis-percentage-track{flex-shrink:0;width:100%}.pvis-metric-scale{justify-content:space-between;display:flex}.pvis-diagnostic-rates{margin-top:16px}.pvis-family-origin{align-items:flex-start;gap:15px;padding:15px 0;display:flex}.pvis-family-origin>svg{color:var(--pvis-mint);flex-shrink:0}.pvis-mechanism{background:var(--soft,#162230);border-radius:10px;margin-top:15px;padding:14px}.pvis-mechanism>div:first-child{align-items:center;gap:12px;display:flex}.pvis-mechanism>div:first-child>span:not(.pvis-mechanism-arrow){flex:1;font-size:12px}.pvis-mechanism-arrow{color:var(--pvis-mint);flex-direction:column;align-items:center;gap:4px;display:flex}.pvis-mechanism-arrow small{font-size:9px}.pvis-mechanism-arrow.is-proposed{color:var(--pvis-lavender)}.pvis-mechanism-arrow.is-proposed svg{stroke-dasharray:3 3}.pvis-open-questions{gap:20px;display:grid}.pvis-open-questions>div{align-items:flex-start;gap:15px;padding:10px 0 20px;display:flex}.pvis-open-questions>div+div{border-top:1px solid var(--line,#233041);padding-top:23px}.pvis-open-questions>div>svg{color:var(--pvis-lavender);flex-shrink:0}.pvis-open-questions h3{font-family:var(--font-display),system-ui, sans-serif;margin-top:7px;font-size:25px;font-weight:600;line-height:1.3}.pvis-finding+.pvis-finding{margin-top:16px}.pvis-source-extract{margin-top:17px;font-size:12px}.pvis-source-extract summary{cursor:pointer;color:var(--pvis-mint)}.pvis-source-extract blockquote{border-left:2px solid var(--line-strong,#354151);color:var(--muted,#9cabc0);margin:12px 0 0;padding:8px 14px}.pvis-percentage{margin-top:18px}.pvis-percentage>div:first-child{justify-content:space-between;align-items:baseline;gap:12px;display:flex}.pvis-percentage b{font-size:12px;font-weight:500}.pvis-percentage strong{font-size:24px;font-weight:400}.pvis-percentage>span{color:var(--muted,#9cabc0);font-size:10px}.pvis-percentage-track{background:var(--pvis-rest);border-radius:3px;height:12px;margin-top:7px;overflow:hidden}.pvis-percentage-track>i{background:var(--pvis-event);height:100%;display:block}.pvis-metric-interval{flex-shrink:0;width:100%;height:31px;margin-top:7px;position:relative}.pvis-metric-interval 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var(--line,#233041)}.pvis-panel-head,.pvis-statistics,.pvis-meaning>div,.pvis-source-trail{padding:22px}.pvis-counts{grid-template-columns:repeat(auto-fit,minmax(125px,1fr));gap:24px}.pvis-count-picture{max-width:180px}.pvis-interval-label small{margin-left:0;display:block}.pvis-interval-label{align-items:flex-start}}@media (max-width:390px){.pvis-wrap{width:calc(100% - 26px)}.pvis-choice{padding:11px}.pvis-design,.pvis-result,.pvis-panel-head,.pvis-statistics,.pvis-meaning>div,.pvis-source-trail{padding:20px 17px}.pvis-counts{grid-template-columns:repeat(auto-fit,minmax(105px,1fr));gap:20px}.pvis-count-picture{gap:2px}.pvis-stat-summary{grid-template-columns:1fr 1fr}}@media (max-width:580px){.pvis-chapters{grid-template-columns:repeat(3,minmax(0,1fr))}.pvis-chapters button{min-height:70px;font-size:10px}}@media (prefers-reduced-motion:reduce){.pvis *,.pvis :before,.pvis 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